Mus musculus Gene: Mapk9
Summary
InnateDB Gene IDBG-167617.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mapk9
Gene Name mitogen-activated protein kinase 9
Synonyms AI851083; JNK2; p54aSAPK; Prkm9;
Species Mus musculus
Ensembl Gene ENSMUSG00000020366
Encoded Proteins
mitogen-activated protein kinase 9
mitogen-activated protein kinase 9
mitogen-activated protein kinase 9
mitogen-activated protein kinase 9
mitogen-activated protein kinase 9
mitogen-activated protein kinase 9
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] MAPK9 phosphorylates IRF3 and is essential for IRF3 dimerization induced by polyinosinic-cytidylic acid (polyI:C).
[Homo sapiens] Upon viral infection, MAVS recruits MKK7 onto mitochondria, leading to the induction of apoptosis by MAP2K7 activated MAPK9
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000050748:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Sep 2008]
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene\'s mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:49846751-49886421
Strand Forward strand
Band B1.2
Transcripts
ENSMUST00000020634 ENSMUSP00000020634
ENSMUST00000043321 ENSMUSP00000042744
ENSMUST00000102778 ENSMUSP00000099839
ENSMUST00000109179 ENSMUSP00000104808
ENSMUST00000109178 ENSMUSP00000104807
ENSMUST00000144857
ENSMUST00000148274
ENSMUST00000151695
ENSMUST00000164643 ENSMUSP00000132864
ENSMUST00000178543 ENSMUSP00000136977
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 64 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 64 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004705 JUN kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008134 transcription factor binding
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0031435 mitogen-activated protein kinase kinase kinase binding
Biological Process
GO:0001836 release of cytochrome c from mitochondria
GO:0001934 positive regulation of protein phosphorylation
GO:0006468 protein phosphorylation
GO:0006626 protein targeting to mitochondrion
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007254 JNK cascade
GO:0007258 JUN phosphorylation
GO:0007417 central nervous system development
GO:0009103 lipopolysaccharide biosynthetic process
GO:0009612 response to mechanical stimulus
GO:0009636 response to toxic substance
GO:0010033 response to organic substance
GO:0010628 positive regulation of gene expression
GO:0010744 positive regulation of macrophage derived foam cell differentiation
GO:0010770 positive regulation of cell morphogenesis involved in differentiation
GO:0014075 response to amine
GO:0031175 neuron projection development
GO:0031394 positive regulation of prostaglandin biosynthetic process
GO:0031396 regulation of protein ubiquitination
GO:0032308 positive regulation of prostaglandin secretion
GO:0032722 positive regulation of chemokine production
GO:0034644 cellular response to UV
GO:0042493 response to drug
GO:0043065 positive regulation of apoptotic process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046328 regulation of JNK cascade
GO:0046686 response to cadmium ion
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
GO:0071222 cellular response to lipopolysaccharide
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0071363 cellular response to growth factor stimulus
GO:2001235 positive regulation of apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Toll Like Receptor 3 (TLR3) Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Innate Immune System pathway
Oxidative Stress Induced Senescence pathway
Activation of the AP-1 family of transcription factors pathway
MAPK targets/ Nuclear events mediated by MAP kinases pathway
Cellular responses to stress pathway
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 pathway
MyD88 cascade initiated on plasma membrane pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
MAP kinase activation in TLR cascade pathway
Immune System pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
Cellular Senescence pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Fc epsilon receptor (FCERI) signaling pathway
Toll-Like Receptors Cascades pathway
MyD88 dependent cascade initiated on endosome pathway
Activated TLR4 signalling pathway
MyD88-independent cascade pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
TRIF-mediated TLR3/TLR4 signaling pathway
FCERI mediated MAPK activation pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
KEGG
MAPK signaling pathway pathway
ErbB signaling pathway pathway
Protein processing in endoplasmic reticulum pathway
Wnt signaling pathway pathway
Osteoclast differentiation pathway
Focal adhesion pathway
Toll-like receptor signaling pathway pathway
NOD-like receptor signaling pathway pathway
RIG-I-like receptor signaling pathway pathway
T cell receptor signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Neurotrophin signaling pathway pathway
Insulin signaling pathway pathway
GnRH signaling pathway pathway
Progesterone-mediated oocyte maturation pathway
Adipocytokine signaling pathway pathway
Type II diabetes mellitus pathway
Chagas disease (American trypanosomiasis) pathway
Toxoplasmosis pathway
Hepatitis C pathway
Pathways in cancer pathway
Colorectal cancer pathway
Pancreatic cancer pathway
INOH
TNFR1 signaling pathway pathway
Fas signaling pathway pathway
TGF-beta signaling pathway
CD4 T cell receptor signaling pathway
IL-7 signaling pathway
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
JAK STAT pathway and regulation pathway
Integrin signaling pathway pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
EGFR1 pathway
TNFalpha pathway
TCR pathway
BCR pathway
IL1 pathway
RANKL pathway
TSLP pathway
TWEAK pathway
Prolactin pathway
REACTOME
Cellular responses to stress pathway
MyD88 dependent cascade initiated on endosome pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
MyD88 cascade initiated on plasma membrane pathway
Innate Immune System pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Activation of the AP-1 family of transcription factors pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
Fc epsilon receptor (FCERI) signaling pathway
MAP kinase activation in TLR cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Immune System pathway
MyD88-independent cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 pathway
Cellular Senescence pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Activated TLR4 signalling pathway
MAPK targets/ Nuclear events mediated by MAP kinases pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Oxidative Stress Induced Senescence pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
FCERI mediated MAPK activation pathway
KEGG
MAPK signaling pathway pathway
ErbB signaling pathway pathway
Protein processing in endoplasmic reticulum pathway
Wnt signaling pathway pathway
Osteoclast differentiation pathway
Focal adhesion pathway
Toll-like receptor signaling pathway pathway
NOD-like receptor signaling pathway pathway
RIG-I-like receptor signaling pathway pathway
T cell receptor signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Neurotrophin signaling pathway pathway
Insulin signaling pathway pathway
GnRH signaling pathway pathway
Progesterone-mediated oocyte maturation pathway
Adipocytokine signaling pathway pathway
Type II diabetes mellitus pathway
Epithelial cell signaling in Helicobacter pylori infection pathway
Shigellosis pathway
Chagas disease (American trypanosomiasis) pathway
Toxoplasmosis pathway
Hepatitis C pathway
Pathways in cancer pathway
Colorectal cancer pathway
Pancreatic cancer pathway
INOH
TNFR1 signaling pathway pathway
Fas signaling pathway pathway
TGF-beta signaling pathway
IL-7 signaling pathway
CD4 T cell receptor signaling pathway
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
JAK STAT pathway and regulation pathway
Integrin signaling pathway pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID BIOCARTA
Mapkinase signaling pathway [Biocarta view]
PID NCI
Regulation of retinoblastoma protein
Downstream signaling in na´ve CD8+ T cells
ATF-2 transcription factor network
RAC1 signaling pathway
CDC42 signaling events
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Cross-References
SwissProt Q9WTU6
TrEMBL
UniProt Splice Variant
Entrez Gene 26420
UniGene Mm.472410 Mm.68933
RefSeq NM_207692 NM_016961 NM_001163671 NM_001163672 XM_006533379
OMIM
CCDS CCDS48783 CCDS24623 CCDS24624 CCDS48782
HPRD
IMGT
MGI ID MGI:1346862
MGI Symbol Mapk9
EMBL AB005664 AF052466 AF052467 AF052468 AF052469 AJ315339 AJ315340 AJ315341 AJ315342 AJ315343 AJ315344 AJ315345 AJ315346 AJ315347 AJ315348 AJ315349 AJ315350 AK031959 AL606479 BC028341
GenPept AAD22576 AAD22577 AAD22578 AAD22579 AAH28341 BAA85876 BAC27623 CAC88132 CAI23940 CAI23941
RNA Seq Atlas 26420