InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mapk9

Summary

InnateDB Gene

IDBG-167617.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mapk9

Gene Name

mitogen-activated protein kinase 9

Synonyms

AI851083; JNK2; p54aSAPK; Prkm9

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020366

Encoded Proteins

IDBP-167619

mitogen-activated protein kinase 9

IDBP-167621

mitogen-activated protein kinase 9

IDBP-167625

mitogen-activated protein kinase 9

IDBP-262958

mitogen-activated protein kinase 9

IDBP-262960

mitogen-activated protein kinase 9

IDBP-621929

mitogen-activated protein kinase 9

IDBP-717938

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 19153595

[Homo sapiens] MAPK9 phosphorylates IRF3 and is essential for IRF3 dimerization induced by polyinosinic-cytidylic acid (polyI:C).

PMID 24651600

[Homo sapiens] Upon viral infection, MAVS recruits MKK7 onto mitochondria, leading to the induction of apoptosis by MAP2K7 activated MAPK9

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000050748:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Sep 2008]
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene\'s mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Sep 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:49846751-49886421

Strand

Forward strand

Band

B1.2

Transcripts

ENSMUST00000020634	ENSMUSP00000020634
ENSMUST00000043321	ENSMUSP00000042744
ENSMUST00000102778	ENSMUSP00000099839
ENSMUST00000109179	ENSMUSP00000104808
ENSMUST00000109178	ENSMUSP00000104807
ENSMUST00000144857
ENSMUST00000148274
ENSMUST00000151695
ENSMUST00000164643	ENSMUSP00000132864
ENSMUST00000178543	ENSMUSP00000136977

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 64 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	64 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004705	JUN kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008134	transcription factor binding
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0031435	mitogen-activated protein kinase kinase kinase binding

Biological Process

GO:0001836	release of cytochrome c from mitochondria
GO:0001934	positive regulation of protein phosphorylation
GO:0006468	protein phosphorylation
GO:0006626	protein targeting to mitochondrion
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007254	JNK cascade
GO:0007258	JUN phosphorylation
GO:0007417	central nervous system development
GO:0009103	lipopolysaccharide biosynthetic process
GO:0009612	response to mechanical stimulus
GO:0009636	response to toxic substance
GO:0010033	response to organic substance
GO:0010628	positive regulation of gene expression
GO:0010744	positive regulation of macrophage derived foam cell differentiation
GO:0010770	positive regulation of cell morphogenesis involved in differentiation
GO:0014075	response to amine
GO:0031175	neuron projection development
GO:0031394	positive regulation of prostaglandin biosynthetic process
GO:0031396	regulation of protein ubiquitination
GO:0032308	positive regulation of prostaglandin secretion
GO:0032722	positive regulation of chemokine production
GO:0034644	cellular response to UV
GO:0042493	response to drug
GO:0043065	positive regulation of apoptotic process
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046328	regulation of JNK cascade
GO:0046686	response to cadmium ion
GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process
GO:0071222	cellular response to lipopolysaccharide
GO:0071347	cellular response to interleukin-1
GO:0071356	cellular response to tumor necrosis factor
GO:0071363	cellular response to growth factor stimulus
GO:2001235	positive regulation of apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0016020	membrane

Orthologs

Species

Homo sapiens

Gene ID

Gene Order

ENSG00000050748

View Gene Order

Pathways

NETPATH

REACTOME

REACT_263316

Toll Like Receptor 3 (TLR3) Cascade pathway

REACT_229712

TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway

REACT_263004

Toll Like Receptor 2 (TLR2) Cascade pathway

REACT_239142

Innate Immune System pathway

REACT_188970

Oxidative Stress Induced Senescence pathway

REACT_204811

Activation of the AP-1 family of transcription factors pathway

REACT_210065

MAPK targets/ Nuclear events mediated by MAP kinases pathway

REACT_188957

Cellular responses to stress pathway

REACT_204812

JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 pathway

REACT_245896

MyD88 cascade initiated on plasma membrane pathway

REACT_255939

Toll Like Receptor TLR1:TLR2 Cascade pathway

REACT_262171

MAP kinase activation in TLR cascade pathway

REACT_230745

Immune System pathway

REACT_260773

Toll Like Receptor 5 (TLR5) Cascade pathway

REACT_254406

Toll Like Receptor TLR6:TLR2 Cascade pathway

REACT_188820

Cellular Senescence pathway

REACT_249409

Toll Like Receptor 9 (TLR9) Cascade pathway

REACT_188204

Fc epsilon receptor (FCERI) signaling pathway

REACT_251547

Toll-Like Receptors Cascades pathway

REACT_256727

MyD88 dependent cascade initiated on endosome pathway

REACT_262462

Activated TLR4 signalling pathway

REACT_241786

MyD88-independent cascade pathway

REACT_242921

Toll Like Receptor 7/8 (TLR7/8) Cascade pathway

REACT_230045

MyD88:Mal cascade initiated on plasma membrane pathway

REACT_238546

TRIF-mediated TLR3/TLR4 signaling pathway

REACT_188530

FCERI mediated MAPK activation pathway

REACT_261340

Toll Like Receptor 10 (TLR10) Cascade pathway

REACT_246719

Toll Like Receptor 4 (TLR4) Cascade pathway

KEGG

mmu04012

ErbB signaling pathway pathway

mmu04930

Type II diabetes mellitus pathway

mmu04910

Insulin signaling pathway pathway

mmu04660

T cell receptor signaling pathway pathway

mmu04310

Wnt signaling pathway pathway

mmu04620

Toll-like receptor signaling pathway pathway

mmu05210

Colorectal cancer pathway

mmu04664

Fc epsilon RI signaling pathway pathway

mmu04912

GnRH signaling pathway pathway

mmu04010

MAPK signaling pathway pathway

mmu04920

Adipocytokine signaling pathway pathway

mmu04510

Focal adhesion pathway

mmu05212

Pancreatic cancer pathway

mmu04722

Neurotrophin signaling pathway pathway

mmu05200

Pathways in cancer pathway

mmu04914

Progesterone-mediated oocyte maturation pathway

mmu04622

RIG-I-like receptor signaling pathway pathway

mmu04621

NOD-like receptor signaling pathway pathway

mmu04380

Osteoclast differentiation pathway

mmu04141

Protein processing in endoplasmic reticulum pathway

mmu05145

Toxoplasmosis pathway

mmu05160

Hepatitis C pathway

mmu05142

Chagas disease (American trypanosomiasis) pathway

INOH