Mus musculus Gene: Rnf25
Summary
InnateDB Gene IDBG-167809.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rnf25
Gene Name ring finger protein 25
Synonyms 0610009H16Rik; AO7;
Species Mus musculus
Ensembl Gene ENSMUSG00000026171
Encoded Proteins
ring finger protein 25
ring finger protein 25
ring finger protein 25
ring finger protein 25
ring finger protein 25
ring finger protein 25
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163481:
The protein encoded by this gene contains a RING finger motif. The mouse counterpart of this protein has been shown to interact with Rela, the p65 subunit of NF-kappaB (NFKB), and modulate NFKB-mediated transcription activity. The mouse protein also binds ubiquitin-conjugating enzymes (E2s) and is a substrate for E2-dependent ubiquitination. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:74593748-74601397
Strand Reverse strand
Band C3
Transcripts
ENSMUST00000027357 ENSMUSP00000027357
ENSMUST00000113721 ENSMUSP00000109350
ENSMUST00000135140 ENSMUSP00000138040
ENSMUST00000149649
ENSMUST00000127938 ENSMUSP00000116973
ENSMUST00000154874 ENSMUSP00000120646
ENSMUST00000151003
ENSMUST00000136078 ENSMUSP00000117692
ENSMUST00000128491
ENSMUST00000132081 ENSMUSP00000115350
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
GO:0051059 NF-kappaB binding
Biological Process
GO:0016567 protein ubiquitination
GO:0051092 positive regulation of NF-kappaB transcription factor activity
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Class I MHC mediated antigen processing & presentation pathway
Immune System pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Adaptive Immune System pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
TNFalpha pathway
REACTOME
Adaptive Immune System pathway
Immune System pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Class I MHC mediated antigen processing & presentation pathway
KEGG
INOH
Tryptophan degradation pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.280920 Mm.468417
RefSeq NM_021313 XM_006496168 XM_006496169 XM_006496170
OMIM
CCDS CCDS15052
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas