InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pstpip1

Summary

InnateDB Gene

IDBG-168522.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pstpip1

Gene Name

proline-serine-threonine phosphatase-interacting protein 1

Synonyms

CD2BP1; def-2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032322

Encoded Proteins

IDBP-168524

proline-serine-threonine phosphatase-interacting protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 17964261

[Homo sapiens] Activates MEFV by binding to the B-Box domain of MEFV and unmasking its PYD domain

PMID 17964261

[Homo sapiens] Enhances binding of MEFV to PYCARD

PMID 14595025

[Homo sapiens] Tyrosine phosphorylation of PSTPIP1 significantly enhances its interaction with MEFV

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140368:
The protein encoded by this gene binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, negatively affecting CD2-triggered T cell activation. The encoded protein appears to be a scaffold protein and a regulator of the actin cytoskeleton. It has also been shown to bind ABL1, PTPN18, WAS, CD2AP, and PTPN12. Mutations in this gene are a cause of PAPA syndrome. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:56089962-56128888

Strand

Forward strand

Band

Transcripts

ENSMUST00000059206	ENSMUSP00000055823
ENSMUST00000147360
ENSMUST00000138646
ENSMUST00000144638
ENSMUST00000135103
ENSMUST00000132800
ENSMUST00000142894

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	43 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0019903	protein phosphatase binding

Biological Process

GO:0006897	endocytosis
GO:0006954	inflammatory response
GO:0007155	cell adhesion
GO:0045087	innate immune response
GO:0055114	oxidation-reduction process

Cellular Component

GO:0001725	stress fiber
GO:0001931	uropod
GO:0005826	actomyosin contractile ring
GO:0016020	membrane
GO:0030027	lamellipodium
GO:0032154	cleavage furrow
GO:0048471	perinuclear region of cytoplasm