Version 5.4
Homo sapiens Gene: GPR124
Summary
InnateDB Gene IDBG-16965.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPR124
Gene Name G protein-coupled receptor 124
Synonyms TEM5
Species Homo sapiens
Ensembl Gene ENSG00000020181
Encoded Proteins
IDBP-16967
G protein-coupled receptor 124
IDBP-366770
G protein-coupled receptor 124
IDBP-366806
G protein-coupled receptor 124
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 8:37784191-37844896
Strand Forward strand
Band p11.23
Transcripts
ENST00000315215 ENSP00000323508
ENST00000428068 ENSP00000400860
ENST00000412232 ENSP00000406367
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
Biological Process
GO:0001525 angiogenesis
GO:0002040 sprouting angiogenesis
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007417 central nervous system development
GO:0010595 positive regulation of endothelial cell migration
GO:0043542 endothelial cell migration
GO:0045765 regulation of angiogenesis
GO:0050920 regulation of chemotaxis
GO:0090210 regulation of establishment of blood-brain barrier
GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031486
View Gene Order
ENSBTAG00000008814
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
avb3_integrin_pathway
Integrins in angiogenesis
Cross-References
SwissProt Q96PE1
TrEMBL
UniProt Splice Variant
Entrez Gene 25960
UniGene Hs.274136
RefSeq NM_032777 XM_006716325
HUGO HGNC:17849
OMIM 606823
CCDS CCDS6097
HPRD 08437
IMGT
EMBL AB040964 AC138356 AF378755 AK027296 AK074099 AL110244 AL832524 AY181242 BC146774 CH471080
GenPept AAI46775 AAL11992 AAO27354 BAA96055 BAB55022 BAB84925 CAB53694 CAD38629 EAW63355 EAW63356
RNA Seq Atlas 25960

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca