Version 5.4
Mus musculus Gene: Dnajb2
Summary
InnateDB Gene IDBG-170401.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dnajb2
Gene Name DnaJ (Hsp40) homolog, subfamily B, member 2
Synonyms 2700059H22Rik; Dnajb10; Hsj1; mDj8
Species Mus musculus
Ensembl Gene ENSMUSG00000026203
Encoded Proteins
IDBP-170405
DnaJ (Hsp40) homolog, subfamily B, member 2
IDBP-170407
DnaJ (Hsp40) homolog, subfamily B, member 2
IDBP-788566
DnaJ (Hsp40) homolog, subfamily B, member 2
IDBP-788567
DnaJ (Hsp40) homolog, subfamily B, member 2
IDBP-788571
DnaJ (Hsp40) homolog, subfamily B, member 2
IDBP-788572
DnaJ (Hsp40) homolog, subfamily B, member 2
IDBP-788573
DnaJ (Hsp40) homolog, subfamily B, member 2
IDBP-788580
DnaJ (Hsp40) homolog, subfamily B, member 2
IDBP-788585
DnaJ (Hsp40) homolog, subfamily B, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135924:
This gene is almost exclusively expressed in the brain, mainly in the neuronal layers. It encodes a protein that shows sequence similarity to bacterial DnaJ protein and the yeast homologs. In bacteria, this protein is implicated in protein folding and protein complex dissociation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:75236406-75245692
Strand Forward strand
Band C4
Transcripts
ENSMUST00000082158 ENSMUSP00000080796
ENSMUST00000055223 ENSMUSP00000052520
ENSMUST00000188931 ENSMUSP00000140566
ENSMUST00000188346 ENSMUSP00000140588
ENSMUST00000188290 ENSMUSP00000140634
ENSMUST00000185403 ENSMUSP00000139982
ENSMUST00000187058 ENSMUSP00000140637
ENSMUST00000185654 ENSMUSP00000140456
ENSMUST00000186600
ENSMUST00000188628
ENSMUST00000190379
ENSMUST00000190445 ENSMUSP00000139573
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030544 Hsp70 protein binding
GO:0031593 polyubiquitin binding
GO:0051082 unfolded protein binding
GO:0051087 chaperone binding
GO:0070628 proteasome binding
Biological Process
GO:0008285 negative regulation of cell proliferation
GO:0030308 negative regulation of cell growth
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
GO:0031398 positive regulation of protein ubiquitination
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0042026 protein refolding
GO:0090084 negative regulation of inclusion body assembly
GO:0090086 negative regulation of protein deubiquitination
Cellular Component
GO:0000502 proteasome complex
GO:0005634 nucleus
GO:0005829 cytosol
GO:0016234 inclusion body
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000135924
View Gene Order
ENSBTAG00000013782
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001159883 NM_001159884 NM_001159885 NM_020266 NM_178055 XM_006496510
OMIM
CCDS CCDS15068 CCDS35624
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca