Homo sapiens Gene: XYLT1
Summary
InnateDB Gene IDBG-17047.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol XYLT1
Gene Name xylosyltransferase I
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000103489
Encoded Proteins
xylosyltransferase I
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This locus encodes a xylosyltransferase enzyme. The encoded protein catalyzes transfer of UDP-xylose to serine residues of an acceptor protein substrate. This transfer reaction is necessary for biosynthesis of glycosaminoglycan chains. Mutations in this gene have been associated with increased severity of pseudoxanthoma elasticum.[provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:17101769-17470881
Strand Reverse strand
Band p12.3
Transcripts
ENST00000261381 ENSP00000261381
ENST00000575674
ENST00000563403
ENST00000568226
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008375 acetylglucosaminyltransferase activity
GO:0030158 protein xylosyltransferase activity
Biological Process
GO:0006024 glycosaminoglycan biosynthetic process
GO:0015012 heparan sulfate proteoglycan biosynthetic process
GO:0030206 chondroitin sulfate biosynthetic process
GO:0034605 cellular response to heat
Cellular Component
GO:0000139 Golgi membrane
GO:0005576 extracellular region
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Glycosaminoglycan biosynthesis pathway
Glycosaminoglycan biosynthesis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.22907 Hs.627781
RefSeq NM_022166
HUGO
OMIM
CCDS CCDS10569
HPRD 12168
IMGT
EMBL
GenPept
RNA Seq Atlas