Mus musculus Gene: Notch4 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-171820.7 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Notch4 | ||||||||||||||||||||||
Gene Name | notch 4 | ||||||||||||||||||||||
Synonyms | Int-3; Int3; N4 | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000015468 | ||||||||||||||||||||||
Encoded Proteins |
Notch gene homolog 4 (Drosophila)
Notch gene homolog 4 (Drosophila)
Notch gene homolog 4 (Drosophila)
Notch gene homolog 4 (Drosophila)
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204301:
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. This gene may be associated with susceptibility to schizophrenia in a small portion of cases. An alternative splice variant has been described but its biological nature has not been determined. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 17:34564268-34588503 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | B1 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME | |||||||||||||||||||||||
KEGG |
Notch signaling pathway pathway
Dorso-ventral axis formation pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH |
Notch pathway
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REACTOME |
Signaling by NOTCH4 pathway
Pre-NOTCH Transcription and Translation pathway
Pre-NOTCH Processing in the Endoplasmic Reticulum pathway
Pre-NOTCH Processing in Golgi pathway
Notch-HLH transcription pathway pathway
Generic Transcription Pathway pathway
Pre-NOTCH Expression and Processing pathway
Signal Transduction pathway
Signaling by NOTCH pathway
Gene Expression pathway
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KEGG |
Notch signaling pathway pathway
Dorso-ventral axis formation pathway
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INOH |
Notch signaling pathway pathway
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PID NCI |
Notch signaling pathway
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Mm.173813 | ||||||||||||||||||||||
RefSeq | NM_010929 XM_006523798 XM_006525349 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS28647 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||