Mus musculus Gene: Hsp90aa1 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-172055.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Hsp90aa1 | ||||||||||||||||||||||
Gene Name | heat shock protein 90, alpha (cytosolic), class A member 1 | ||||||||||||||||||||||
Synonyms | 86kDa; 89kDa; AL024080; AL024147; hsp4; Hsp86-1; Hsp89; Hsp90; Hspca | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000021270 | ||||||||||||||||||||||
Encoded Proteins |
heat shock protein 90, alpha (cytosolic), class A member 1
heat shock protein 90, alpha (cytosolic), class A member 1
heat shock protein 90, alpha (cytosolic), class A member 1
heat shock protein 90, alpha (cytosolic), class A member 1
heat shock protein 90, alpha (cytosolic), class A member 1
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||||||||||
Summary |
[Homo sapiens] HSP90AA1 (HSP90) positively regulates NOD1 activation.
[Homo sapiens] HSP90AA1 regulates the stability of transforming growth factor beta-activated kinase 1 (TAK1) in interleukin-1beta (IL1B)-induced cell signalling and IL1B-induced signalling by interacting with and maintaining the stability of TAK1, suggesting that HSP90AA1 might act as the chaperone of TAK1 in immune and inflammatory responses related with IL1A (IL-1) signal cascades.
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Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000080824:
The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 12:110690605-110702728 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | F1 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
They are also associated with 693 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation pathway
Recruitment of mitotic centrosome proteins and complexes pathway
Innate Immune System pathway
Regulation of actin dynamics for phagocytic cup formation pathway
G2/M Transition pathway
Signaling by ERBB2 pathway
Cell Cycle, Mitotic pathway
Disease pathway
Signaling by constitutively active EGFR pathway
eNOS activation and regulation pathway
Loss of Nlp from mitotic centrosomes pathway
eNOS activation pathway
Cellular responses to stress pathway
Signaling by VEGF pathway
EPHA-mediated growth cone collapse pathway
Sema3A PAK dependent Axon repulsion pathway
Cell Cycle pathway
Metabolism pathway
Immune System pathway
Binding and Uptake of Ligands by Scavenger Receptors pathway
HSF1-dependent transactivation pathway
Mitotic G2-G2/M phases pathway
Cellular response to heat stress pathway
EPH-Ephrin signaling pathway
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
VEGFR2 mediated vascular permeability pathway
VEGFA-VEGFR2 Pathway pathway
Axon guidance pathway
Attenuation phase pathway
Regulation of PLK1 Activity at G2/M Transition pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
HSF1 activation pathway
Developmental Biology pathway
Scavenging by Class F Receptors pathway
Metabolism of nitric oxide pathway
Semaphorin interactions pathway
Signal Transduction pathway
Signaling by EGFR in Cancer pathway
Centrosome maturation pathway
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KEGG |
Antigen processing and presentation pathway
Prostate cancer pathway
Pathways in cancer pathway
Progesterone-mediated oocyte maturation pathway
NOD-like receptor signaling pathway pathway
Protein processing in endoplasmic reticulum pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH |
AndrogenReceptor pathway
TNFalpha pathway
IL2 pathway
IL6 pathway
RANKL pathway
TSLP pathway
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REACTOME |
Regulation of PLK1 Activity at G2/M Transition pathway
Loss of Nlp from mitotic centrosomes pathway
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
Recruitment of mitotic centrosome proteins and complexes pathway
Regulation of actin dynamics for phagocytic cup formation pathway
Signaling by ERBB2 pathway
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation pathway
eNOS activation pathway
Signaling by constitutively active EGFR pathway
vRNP Assembly pathway
Sema3A PAK dependent Axon repulsion pathway
Cellular responses to stress pathway
Developmental Biology pathway
Signaling by EGFR in Cancer pathway
Influenza Infection pathway
Semaphorin interactions pathway
eNOS activation and regulation pathway
Scavenging by Class F Receptors pathway
Signaling by VEGF pathway
Innate Immune System pathway
Attenuation phase pathway
Metabolism of nitric oxide pathway
VEGFR2 mediated vascular permeability pathway
Axon guidance pathway
Influenza Viral RNA Transcription and Replication pathway
Binding and Uptake of Ligands by Scavenger Receptors pathway
Signal Transduction pathway
Cell Cycle pathway
Immune System pathway
EPHA-mediated growth cone collapse pathway
Centrosome maturation pathway
HSF1-dependent transactivation pathway
VEGFA-VEGFR2 Pathway pathway
G2/M Transition pathway
Cellular response to heat stress pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
Cell Cycle, Mitotic pathway
EPH-Ephrin signaling pathway
Influenza Life Cycle pathway
Mitotic G2-G2/M phases pathway
Metabolism pathway
HSF1 activation pathway
Disease pathway
G2/M Transition pathway
EPHA-mediated growth cone collapse pathway
HSF1-dependent transactivation pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
eNOS activation pathway
eNOS activation and regulation pathway
Metabolism of nitric oxide pathway
Cellular responses to stress pathway
VEGFA-VEGFR2 Pathway pathway
Scavenging by Class F Receptors pathway
Immune System pathway
Cell Cycle, Mitotic pathway
Loss of Nlp from mitotic centrosomes pathway
Mitotic G2-G2/M phases pathway
EPH-Ephrin signaling pathway
Signaling by ERBB2 pathway
Cell Cycle pathway
Signal Transduction pathway
VEGFR2 mediated vascular permeability pathway
HSF1 activation pathway
Signaling by EGFR in Cancer pathway
Regulation of actin dynamics for phagocytic cup formation pathway
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
Axon guidance pathway
Binding and Uptake of Ligands by Scavenger Receptors pathway
Signaling by constitutively active EGFR pathway
Metabolism pathway
Signaling by VEGF pathway
Cellular response to heat stress pathway
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation pathway
Regulation of PLK1 Activity at G2/M Transition pathway
Recruitment of mitotic centrosome proteins and complexes pathway
Centrosome maturation pathway
Attenuation phase pathway
Innate Immune System pathway
Disease pathway
Semaphorin interactions pathway
Developmental Biology pathway
Sema3A PAK dependent Axon repulsion pathway
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KEGG |
Antigen processing and presentation pathway
Prostate cancer pathway
Pathways in cancer pathway
Progesterone-mediated oocyte maturation pathway
NOD-like receptor signaling pathway pathway
Protein processing in endoplasmic reticulum pathway
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INOH | |||||||||||||||||||||||
PID NCI |
Class I PI3K signaling events
Class I PI3K signaling events mediated by Akt
Integrins in angiogenesis
Validated targets of C-MYC transcriptional activation
LKB1 signaling events
Integrin-linked kinase signaling
Glucocorticoid receptor regulatory network
Signaling events mediated by HDAC Class II
ErbB receptor signaling network
Signaling events mediated by VEGFR1 and VEGFR2
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
Regulation of Androgen receptor activity
VEGFR1 specific signals
IL2 signaling events mediated by PI3K
Regulation of Telomerase
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Mm.341186 Mm.398379 Mm.399373 Mm.400443 Mm.424044 Mm.465441 Mm.474664 | ||||||||||||||||||||||
RefSeq | NM_010480 XM_006515485 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS26172 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||