InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Uba3

Summary

InnateDB Gene

IDBG-172168.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Uba3

Gene Name

ubiquitin-like modifier activating enzyme 3

Synonyms

A830034N06Rik; AI256736; AI848246; AW546539; Ube1c

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030061

Encoded Proteins

IDBP-172172

ubiquitin-like modifier activating enzyme 3

IDBP-622779

ubiquitin-like modifier activating enzyme 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is the catalytic subunit of the enzyme that activates NEDD8, a ubiquitin-like molecule that binds to its target proteins through an enzymatic reaction analagous to ubiquitylation. Embryonic mice deficient for this protein die prior to implantation and display apoptosis of the inner cell mass. Trophoblastic cells cannot enter S phase, demonstrating that this gene is required for cell cycle progression during embryogenesis. Two pseudogenes have been found for this gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:97183670-97205642

Strand

Reverse strand

Band

Transcripts

ENSMUST00000089287	ENSMUSP00000086701
ENSMUST00000164744	ENSMUSP00000130954

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008641	small protein activating enzyme activity
GO:0016881	acid-amino acid ligase activity
GO:0019781	NEDD8 activating enzyme activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000278	mitotic cell cycle
GO:0006464	cellular protein modification process
GO:0007113	endomitotic cell cycle
GO:0045116	protein neddylation
GO:0051726	regulation of cell cycle