Homo sapiens Gene: RPS15A
Summary
InnateDB Gene IDBG-17259.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RPS15A
Gene Name ribosomal protein S15a
Synonyms S15a;
Species Homo sapiens
Ensembl Gene ENSG00000134419
Encoded Proteins
ribosomal protein S15a
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S8P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:18781295-18790383
Strand Reverse strand
Band p12.3
Transcripts
ENST00000322989 ENSP00000318646
ENST00000562935 ENSP00000457001
ENST00000576436 ENSP00000459554
ENST00000575669
ENST00000563390 ENSP00000457000
ENST00000565420 ENSP00000458115
ENST00000574723 ENSP00000460069
ENST00000569365 ENSP00000457924
ENST00000576008 ENSP00000459373
ENST00000573554
ENST00000572008 ENSP00000458528
ENST00000569083 ENSP00000460618
ENST00000563579 ENSP00000458052
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 148 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 148 [view]
Protein-Protein 148 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006412 translation
GO:0006413 translational initiation
GO:0006414 translational elongation
GO:0006415 translational termination
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0008284 positive regulation of cell proliferation
GO:0009615 response to virus
GO:0010467 gene expression
GO:0016032 viral process
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0019058 viral life cycle
GO:0019083 viral transcription
GO:0044267 cellular protein metabolic process
GO:0045787 positive regulation of cell cycle
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0016020 membrane
GO:0022627 cytosolic small ribosomal subunit
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Eukaryotic Translation Initiation pathway
Influenza Infection pathway
SRP-dependent cotranslational protein targeting to membrane pathway
Nonsense-Mediated Decay (NMD) pathway
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) pathway
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
Formation of a pool of free 40S subunits pathway
Influenza Viral RNA Transcription and Replication pathway
Translation pathway
Translation initiation complex formation pathway
Eukaryotic Translation Termination pathway
Metabolism of proteins pathway
Cap-dependent Translation Initiation pathway
Ribosomal scanning and start codon recognition pathway
Eukaryotic Translation Elongation pathway
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
Influenza Life Cycle pathway
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
Formation of the ternary complex, and subsequently, the 43S complex pathway
Viral mRNA Translation pathway
Peptide chain elongation pathway
L13a-mediated translational silencing of Ceruloplasmin expression pathway
Gene Expression pathway
Disease pathway
KEGG
Ribosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.633952 Hs.731620
RefSeq NM_001019 NM_001030009
HUGO
OMIM
CCDS CCDS10571
HPRD 04723
IMGT
EMBL
GenPept
RNA Seq Atlas