Mus musculus Gene: Actr1a
Summary
InnateDB Gene IDBG-173074.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Actr1a
Gene Name ARP1 actin-related protein 1A, centractin alpha
Synonyms alpha-Arp1; Arp1
Species Mus musculus
Ensembl Gene ENSMUSG00000025228
Encoded Proteins
ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138107:
This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin. [provided by RefSeq, Jul 2008]
This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60%% identical at the amino acid level to conventional actin. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:46376814-46395735
Strand Reverse strand
Band C3
Transcripts
ENSMUST00000040270 ENSMUSP00000039844
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
Biological Process
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Recruitment of mitotic centrosome proteins and complexes pathway
G2/M Transition pathway
Cell Cycle, Mitotic pathway
Loss of Nlp from mitotic centrosomes pathway
Cell Cycle pathway
Immune System pathway
Mitotic G2-G2/M phases pathway
MHC class II antigen presentation pathway
Loss of proteins required for interphase microtubule organization√?¬†from the centrosome pathway
Regulation of PLK1 Activity at G2/M Transition pathway
Adaptive Immune System pathway
Centrosome maturation pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Regulation of PLK1 Activity at G2/M Transition pathway
Loss of Nlp from mitotic centrosomes pathway
Loss of proteins required for interphase microtubule organization√?¬†from the centrosome pathway
Recruitment of mitotic centrosome proteins and complexes pathway
MHC class II antigen presentation pathway
Cell Cycle pathway
Adaptive Immune System pathway
Immune System pathway
Centrosome maturation pathway
G2/M Transition pathway
Cell Cycle, Mitotic pathway
Mitotic G2-G2/M phases pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P61164
TrEMBL
UniProt Splice Variant
Entrez Gene 54130
UniGene Mm.3118 Mm.408394
RefSeq NM_016860
OMIM
CCDS CCDS29878
HPRD
IMGT
MGI ID MGI:1858964
MGI Symbol Actr1a
EMBL AB010297 AK010632 AK088062 AK167450 AK168889 BC007131
GenPept AAH07131 BAA24423 BAB27076 BAC40124 BAE39536 BAE40706
RNA Seq Atlas 54130