Version 5.4
Mus musculus Gene: Actr1a
Summary
InnateDB Gene IDBG-173074.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Actr1a
Gene Name ARP1 actin-related protein 1A, centractin alpha
Synonyms alpha-Arp1; Arp1
Species Mus musculus
Ensembl Gene ENSMUSG00000025228
Encoded Proteins
IDBP-173076
ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138107:
This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin. [provided by RefSeq, Jul 2008]
This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60%% identical at the amino acid level to conventional actin. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:46376814-46395735
Strand Reverse strand
Band C3
Transcripts
ENSMUST00000040270 ENSMUSP00000039844
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
Biological Process
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000138107
View Gene Order
ENSBTAG00000021067
Not yet available
Pathways
NETPATH
REACTOME
REACT_245720
Recruitment of mitotic centrosome proteins and complexes pathway
REACT_240530
G2/M Transition pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_243078
Loss of Nlp from mitotic centrosomes pathway
REACT_188804
Cell Cycle pathway
REACT_230745
Immune System pathway
REACT_246508
Mitotic G2-G2/M phases pathway
REACT_196550
MHC class II antigen presentation pathway
REACT_244487
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
REACT_196635
Regulation of PLK1 Activity at G2/M Transition pathway
REACT_229531
Adaptive Immune System pathway
REACT_253753
Centrosome maturation pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_160315
Regulation of PLK1 Activity at G2/M Transition pathway
REACT_15364
Loss of Nlp from mitotic centrosomes pathway
REACT_15451
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
REACT_15296
Recruitment of mitotic centrosome proteins and complexes pathway
REACT_121399
MHC class II antigen presentation pathway
REACT_115566
Cell Cycle pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_15479
Centrosome maturation pathway
REACT_2203
G2/M Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_21391
Mitotic G2-G2/M phases pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P61164
TrEMBL
UniProt Splice Variant
Entrez Gene 54130
UniGene Mm.3118 Mm.408394
RefSeq NM_016860
OMIM
CCDS CCDS29878
HPRD
IMGT
MGI ID MGI:1858964
MGI Symbol Actr1a
EMBL AB010297 AK010632 AK088062 AK167450 AK168889 BC007131
GenPept AAH07131 BAA24423 BAB27076 BAC40124 BAE39536 BAE40706
RNA Seq Atlas 54130

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca