InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cebpg

Summary

InnateDB Gene

IDBG-173696.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cebpg

Gene Name

CCAAT/enhancer binding protein (C/EBP), gamma

Synonyms

C/EBP[g]; C/EBPgamma; GPE1-BP; Gpe1bp; Ig/EBP

Species

Mus musculus

Ensembl Gene

ENSMUSG00000056216

Encoded Proteins

IDBP-173698

CCAAT/enhancer binding protein (C/EBP), gamma

IDBP-540297

CCAAT/enhancer binding protein (C/EBP), gamma

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000153879:
The C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription. C/EBP proteins contain the bZIP region, which is characterized by two motifs in the C-terminal half of the protein: a basic region involved in DNA binding and a leucine zipper motif involved in dimerization. The C/EBP family consist of several related proteins, C/EBP alpha, C/EBP beta, C/EBP gamma, and C/EBP delta, that form homodimers and that form heterodimers with each other. CCAAT/enhancer binding protein gamma may cooperate with Fos to bind PRE-I enhancer elements. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:35046422-35056503

Strand

Reverse strand

Band

Transcripts

ENSMUST00000070191	ENSMUSP00000064963
ENSMUST00000130491	ENSMUSP00000118588

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	3 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001889	liver development
GO:0006337	nucleosome disassembly
GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006955	immune response
GO:0016071	mRNA metabolic process
GO:0030183	B cell differentiation
GO:0042267	natural killer cell mediated cytotoxicity
GO:0043353	enucleate erythrocyte differentiation
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045078	positive regulation of interferon-gamma biosynthetic process
GO:0045739	positive regulation of DNA repair

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000153879

View Gene Order

ENSBTAG00000017560

Not yet available

Cross-References

SwissProt

P53568

TrEMBL

Q54AJ1

UniProt Splice Variant

Entrez Gene

12611

UniGene

Mm.273090 Mm.465033

RefSeq

NM_009884 XM_006539500

OMIM

CCDS

CCDS21144

HPRD

IMGT

MGI ID

MGI:104982

MGI Symbol

Cebpg

EMBL

AB012273 AB012275 AK050634 AK157391 AK159544 AK169583 AK171859 BC011319 CH466618 X55499

GenPept

AAH11319 BAA25311 BAA25312 BAC34355 BAE34076 BAE35170 BAE41241 BAE42702 CAA39116 EDL03028

RNA Seq Atlas

12611