Mus musculus Gene: Itga11
Summary
InnateDB Gene IDBG-174766.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Itga11
Gene Name integrin alpha 11
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000032243
Encoded Proteins
integrin alpha 11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137809:
This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:62677826-62783982
Strand Forward strand
Band B
Transcripts
ENSMUST00000034774 ENSMUSP00000034774
ENSMUST00000159012
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005518 collagen binding
GO:0038064 collagen receptor activity
Biological Process
GO:0001649 osteoblast differentiation
GO:0006929 substrate-dependent cell migration
GO:0007160 cell-matrix adhesion
GO:0033627 cell adhesion mediated by integrin
GO:0038065 collagen-activated signaling pathway
Cellular Component
GO:0005925 focal adhesion
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Focal adhesion pathway
ECM-receptor interaction pathway
Regulation of actin cytoskeleton pathway
Hypertrophic cardiomyopathy (HCM) pathway
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
Dilated cardiomyopathy pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Extracellular matrix organization pathway
Integrin cell surface interactions pathway
KEGG
Focal adhesion pathway
ECM-receptor interaction pathway
Regulation of actin cytoskeleton pathway
Hypertrophic cardiomyopathy (HCM) pathway
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
Dilated cardiomyopathy pathway
INOH
Integrin signaling pathway pathway
PID BIOCARTA
PID NCI
Beta1 integrin cell surface interactions
Integrin family cell surface interactions
Cross-References
SwissProt
TrEMBL Q8CE84
UniProt Splice Variant
Entrez Gene 319480
UniGene Mm.34883
RefSeq NM_176922
OMIM
CCDS CCDS23265
HPRD
IMGT
MGI ID MGI:2442114
MGI Symbol Itga11
EMBL AK028821
GenPept BAC26137
RNA Seq Atlas 319480