InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DRD4

Summary

InnateDB Gene

IDBG-17519.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DRD4

Gene Name

dopamine receptor D4

Synonyms

D4DR

Species

Homo sapiens

Ensembl Gene

ENSG00000069696

Encoded Proteins

IDBP-17521

dopamine receptor D4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:637293-640706

Strand

Forward strand

Band

p15.5

Transcripts

ENST00000176183	ENSP00000176183
ENST00000528733

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go
GO:0004930	G-protein coupled receptor activity
GO:0004952	dopamine receptor activity
GO:0005515	protein binding
GO:0008144	drug binding
GO:0015459	potassium channel regulator activity
GO:0017124	SH3 domain binding
GO:0035240	dopamine binding
GO:0042802	identical protein binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0001662	behavioral fear response
GO:0001963	synaptic transmission, dopaminergic
GO:0001975	response to amphetamine
GO:0006874	cellular calcium ion homeostasis
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007194	negative regulation of adenylate cyclase activity
GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway
GO:0007212	dopamine receptor signaling pathway
GO:0007614	short-term memory
GO:0007623	circadian rhythm
GO:0008306	associative learning
GO:0008344	adult locomotory behavior
GO:0008355	olfactory learning
GO:0009648	photoperiodism
GO:0030818	negative regulation of cAMP biosynthetic process
GO:0032417	positive regulation of sodium:proton antiporter activity
GO:0033674	positive regulation of kinase activity
GO:0034776	response to histamine
GO:0035176	social behavior
GO:0042053	regulation of dopamine metabolic process
GO:0042417	dopamine metabolic process
GO:0042596	fear response
GO:0042752	regulation of circadian rhythm
GO:0046928	regulation of neurotransmitter secretion
GO:0048148	behavioral response to cocaine
GO:0048149	behavioral response to ethanol
GO:0048545	response to steroid hormone
GO:0050482	arachidonic acid secretion
GO:0050709	negative regulation of protein secretion
GO:0050804	regulation of synaptic transmission
GO:0050848	regulation of calcium-mediated signaling
GO:0051586	positive regulation of dopamine uptake involved in synaptic transmission
GO:0060041	retina development in camera-type eye
GO:0060080	regulation of inhibitory postsynaptic membrane potential
GO:0060406	positive regulation of penile erection
GO:1901386	negative regulation of voltage-gated calcium channel activity
GO:2000463	positive regulation of excitatory postsynaptic membrane potential

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005938	cell cortex
GO:0012506	vesicle membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0043195	terminal bouton
GO:0043197	dendritic spine
GO:0043679	axon terminus