Version 5.4
Homo sapiens Gene: DRD4
Summary
InnateDB Gene IDBG-17519.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DRD4
Gene Name dopamine receptor D4
Synonyms D4DR;
Species Homo sapiens
Ensembl Gene ENSG00000069696
Encoded Proteins
IDBP-17521
dopamine receptor D4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:637293-640706
Strand Forward strand
Band p15.5
Transcripts
ENST00000176183 ENSP00000176183
ENST00000528733
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go
GO:0004930 G-protein coupled receptor activity
GO:0004952 dopamine receptor activity
GO:0005515 protein binding
GO:0008144 drug binding
GO:0015459 potassium channel regulator activity
GO:0017124 SH3 domain binding
GO:0035240 dopamine binding
GO:0042802 identical protein binding
Biological Process
GO:0000187 activation of MAPK activity
GO:0001662 behavioral fear response
GO:0001963 synaptic transmission, dopaminergic
GO:0001975 response to amphetamine
GO:0006874 cellular calcium ion homeostasis
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007194 negative regulation of adenylate cyclase activity
GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway
GO:0007212 dopamine receptor signaling pathway
GO:0007614 short-term memory
GO:0007623 circadian rhythm
GO:0008306 associative learning
GO:0008344 adult locomotory behavior
GO:0008355 olfactory learning
GO:0009648 photoperiodism
GO:0030818 negative regulation of cAMP biosynthetic process
GO:0032417 positive regulation of sodium:proton antiporter activity
GO:0033674 positive regulation of kinase activity
GO:0034776 response to histamine
GO:0035176 social behavior
GO:0042053 regulation of dopamine metabolic process
GO:0042417 dopamine metabolic process
GO:0042596 fear response
GO:0042752 regulation of circadian rhythm
GO:0046928 regulation of neurotransmitter secretion
GO:0048148 behavioral response to cocaine
GO:0048149 behavioral response to ethanol
GO:0048545 response to steroid hormone
GO:0050482 arachidonic acid secretion
GO:0050709 negative regulation of protein secretion
GO:0050804 regulation of synaptic transmission
GO:0050848 regulation of calcium-mediated signaling
GO:0051586 positive regulation of dopamine uptake involved in synaptic transmission
GO:0060041 retina development in camera-type eye
GO:0060080 regulation of inhibitory postsynaptic membrane potential
GO:0060406 positive regulation of penile erection
GO:1901386 negative regulation of voltage-gated calcium channel activity
GO:2000463 positive regulation of excitatory postsynaptic membrane potential
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005938 cell cortex
GO:0012506 vesicle membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0043025 neuronal cell body
GO:0043195 terminal bouton
GO:0043197 dendritic spine
GO:0043679 axon terminus
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
ENSMUSG00000025496
View Gene Order
RBBH
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_16983
Amine ligand-binding receptors pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_19231
G alpha (i) signalling events pathway
REACT_16968
Dopamine receptors pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
INOH website
GPCR signaling pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt P21917
TrEMBL K9MAQ3 Q76E76 Q8WTT3 Q8WTT6 Q99587
UniProt Splice Variant
Entrez Gene 1815
UniGene
RefSeq NM_000797
HUGO HGNC:3025
OMIM 126452
CCDS CCDS7710
HPRD
IMGT
EMBL AB065765 AB107017 AB107018 AB107019 AF395218 AF395219 AF395220 AF395221 AF395228 AP006284 CH471158 EF489034 EU432112 HM191418 HM191419 JQ064942 L12397 L12398 S82918
GenPept AAB46803 AAB59386 AAL35167 AAL35168 AAL35169 AAL35170 AAL35177 AAL58637 ABO48381 ABY87911 AEE60852 AEE60853 AFU07579 BAC05985 BAD00718 BAD00719 BAD00720 EAX02369
RNA Seq Atlas 1815

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca