Mus musculus Gene: Stil
Summary
InnateDB Gene IDBG-175670.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Stil
Gene Name Scl/Tal1 interrupting locus
Synonyms Sil;
Species Mus musculus
Ensembl Gene ENSMUSG00000028718
Encoded Proteins
Scl/Tal1 interrupting locus
Scl/Tal1 interrupting locus
Scl/Tal1 interrupting locus
Scl/Tal1 interrupting locus
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000123473:
This gene encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes to daughter cells. The protein is phosphorylated in mitosis and in response to activation of the spindle checkpoint, and disappears when cells transition to G1 phase. It interacts with a mitotic regulator, and its expression is required to efficiently activate the spindle checkpoint. It is proposed to regulate Cdc2 kinase activity during spindle checkpoint arrest. Chromosomal deletions that fuse this gene and the adjacent locus commonly occur in T cell leukemias, and are thought to arise through illegitimate V-(D)-J recombination events. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:115000159-115043196
Strand Forward strand
Band D1
Transcripts
ENSMUST00000030490 ENSMUSP00000030490
ENSMUST00000141933 ENSMUSP00000118849
ENSMUST00000129957 ENSMUSP00000123385
ENSMUST00000147519 ENSMUSP00000120836
ENSMUST00000130401
ENSMUST00000144316
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000578 embryonic axis specification
GO:0001701 in utero embryonic development
GO:0001843 neural tube closure
GO:0001947 heart looping
GO:0007224 smoothened signaling pathway
GO:0007368 determination of left/right symmetry
GO:0021915 neural tube development
GO:0030900 forebrain development
GO:0030903 notochord development
GO:0033504 floor plate development
GO:0035264 multicellular organism growth
GO:0043066 negative regulation of apoptotic process
Cellular Component
GO:0005813 centrosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Signaling events mediated by the Hedgehog family
Cross-References
SwissProt
TrEMBL A2AD39 D6RH61 F6VXM5 F6WX10 Q8BQI9
UniProt Splice Variant
Entrez Gene 20460
UniGene Mm.3988
RefSeq NM_009185 XM_006502902 XM_006502905 XM_006502906 XM_006502907
OMIM
CCDS CCDS18485
HPRD
IMGT
MGI ID MGI:107477
MGI Symbol Stil
EMBL AK049550 AL670035
GenPept BAC33806
RNA Seq Atlas 20460