InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PHKG1

Summary

InnateDB Gene

IDBG-17586.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PHKG1

Gene Name

phosphorylase kinase, gamma 1 (muscle)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000164776

Encoded Proteins

IDBP-17588

phosphorylase kinase, gamma 1 (muscle)

IDBP-239573

phosphorylase kinase, gamma 1 (muscle)

IDBP-376154

phosphorylase kinase, gamma 1 (muscle)

IDBP-376156

phosphorylase kinase, gamma 1 (muscle)

IDBP-590774

phosphorylase kinase, gamma 1 (muscle)

IDBP-589872

phosphorylase kinase, gamma 1 (muscle)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the Ser/Thr protein kinase family and encodes a protein with one protein kinase domain and two calmodulin-binding domains. This protein is the catalytic member of a 16 subunit protein kinase complex which contains equimolar ratios of 4 subunit types. The complex is a crucial glycogenolytic regulatory enzyme. This gene has two pseudogenes at chromosome 7q11.21 and one at chromosome 11p11.12. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:56080283-56092996

Strand

Reverse strand

Band

p11.2

Transcripts

ENST00000297373	ENSP00000297373
ENST00000395428	ENSP00000378817
ENST00000446428	ENSP00000389721
ENST00000432123	ENSP00000397193
ENST00000452681	ENSP00000445440
ENST00000471665
ENST00000489604
ENST00000467726
ENST00000492124
ENST00000537360	ENSP00000441528

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004689	phosphorylase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0019899	enzyme binding
GO:0050321	tau-protein kinase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0005977	glycogen metabolic process
GO:0005978	glycogen biosynthetic process
GO:0005980	glycogen catabolic process
GO:0006006	glucose metabolic process
GO:0006468	protein phosphorylation
GO:0009103	lipopolysaccharide biosynthetic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005829	cytosol
GO:0005964	phosphorylase kinase complex
GO:0016020	membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000025537

View Gene Order

ENSBTAG00000008195

Not yet available

Pathways

NETPATH

REACTOME

REACT_1008

Glycogen breakdown (glycogenolysis) pathway

REACT_200783

Myoclonic epilepsy of Lafora pathway

REACT_474

Metabolism of carbohydrates pathway

REACT_111217

Metabolism pathway

REACT_116125

Disease pathway

REACT_723

Glucose metabolism pathway

REACT_200833

Glycogen storage diseases pathway

KEGG

hsa04910

Insulin signaling pathway pathway

hsa04020

Calcium signaling pathway pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.730821 Hs.741525

RefSeq

NM_001258459 NM_001258460 NM_006213

HUGO

OMIM

CCDS

CCDS5525 CCDS59057

HPRD

01404

IMGT

EMBL

GenPept

RNA Seq Atlas