Version 5.4
Mus musculus Gene: Bcl9
Summary
InnateDB Gene IDBG-176803.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Bcl9
Gene Name B cell CLL/lymphoma 9
Synonyms 2610202E01Rik; 8030475K17Rik; A330041G23Rik; Gm130
Species Mus musculus
Ensembl Gene ENSMUSG00000038256
Encoded Proteins
IDBP-176805
B-cell CLL/lymphoma 9
IDBP-624931
B-cell CLL/lymphoma 9
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116128:
BCL9 is associated with B-cell acute lymphoblastic leukemia. It may be a target of translocation in B-cell malignancies with abnormalities of 1q21. Its function is unknown. The overexpression of BCL9 may be of pathogenic significance in B-cell malignancies. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:97203662-97228846
Strand Reverse strand
Band F2.1
Transcripts
ENSMUST00000046521 ENSMUSP00000046152
ENSMUST00000132266
ENSMUST00000141861
ENSMUST00000134695
ENSMUST00000135247
ENSMUST00000127319
ENSMUST00000166341 ENSMUSP00000131692
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008013 beta-catenin binding
Biological Process
GO:0014908 myotube differentiation involved in skeletal muscle regeneration
GO:0035019 somatic stem cell maintenance
GO:0035914 skeletal muscle cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060070 canonical Wnt signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005801 cis-Golgi network
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000116128
View Gene Order
ENSBTAG00000002422
Not yet available
Pathways
NETPATH
REACTOME
REACT_189085
Disease pathway
REACT_214014
Signaling by Wnt pathway
REACT_233046
Signaling by WNT in cancer pathway
REACT_219771
deactivation of the beta-catenin transactivating complex pathway
REACT_216539
formation of the beta-catenin:TCF transactivating complex pathway
REACT_262115
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_241644
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_207044
TCF dependent signaling in response to WNT pathway
REACT_188257
Signal Transduction pathway
REACT_241402
XAV939 inhibits tankyrase, stabilizing AXIN pathway
KEGG
INOH
INOH website
Wnt signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_8
Wnt pathway
REACTOME
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_11045
Signaling by Wnt pathway
REACT_200731
deactivation of the beta-catenin transactivating complex pathway
REACT_111102
Signal Transduction pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_200753
formation of the beta-catenin:TCF transactivating complex pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_116125
Disease pathway
KEGG
INOH
INOH website
Wnt signaling pathway pathway
PID NCI
betacatenin_nuc_pathway
Regulation of nuclear beta catenin signaling and target gene transcription
Cross-References
SwissProt Q9D219
TrEMBL
UniProt Splice Variant
Entrez Gene 77578
UniGene Mm.226175 Mm.482931
RefSeq NM_029933 XM_006502288 XM_006502289 XM_006502290
OMIM
CCDS CCDS17654
HPRD
IMGT
MGI ID MGI:1924828
MGI Symbol Bcl9
EMBL AK020724 AK084676 AY296061 BC019641 BC137850
GenPept AAH19641 AAI37851 AAQ62699 BAB32190 BAC39248
RNA Seq Atlas 77578

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca