Version 5.4
Mus musculus Gene: Dapk3
Summary
InnateDB Gene IDBG-177264.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dapk3
Gene Name death-associated protein kinase 3
Synonyms dlk; ZIPK
Species Mus musculus
Ensembl Gene ENSMUSG00000034974
Encoded Proteins
IDBP-177266
death-associated protein kinase 3
IDBP-713609
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167657:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis. [provided by RefSeq, Jul 2008]
Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:81183007-81193197
Strand Forward strand
Band C1
Transcripts
ENSMUST00000047665 ENSMUSP00000035962
ENSMUST00000178422 ENSMUSP00000137333
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004683 calmodulin-dependent protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043522 leucine zipper domain binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0009103 lipopolysaccharide biosynthetic process
GO:0016568 chromatin modification
GO:0017148 negative regulation of translation
GO:0030182 neuron differentiation
GO:0035556 intracellular signal transduction
GO:0042981 regulation of apoptotic process
GO:0046777 protein autophosphorylation
GO:0071346 cellular response to interferon-gamma
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0097190 apoptotic signaling pathway
GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0016020 membrane
GO:0016605 PML body
GO:0045121 membrane raft
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000167657
View Gene Order
ENSBTAG00000020417
Not yet available
Pathways
NETPATH
REACTOME
REACT_258521
Apoptosis pathway
REACT_252543
Role of DCC in regulating apoptosis pathway
REACT_227606
Regulation of Apoptosis pathway
KEGG
mmu05219
Bladder cancer pathway
mmu05200
Pathways in cancer pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
REACT_22128
Role of DCC in regulating apoptosis pathway
REACT_578
Apoptosis pathway
REACT_13648
Regulation of Apoptosis pathway
KEGG
hsa05219
Bladder cancer pathway
hsa05200
Pathways in cancer pathway
INOH
PID NCI
Cross-References
SwissProt O54784
TrEMBL Q05A21
UniProt Splice Variant
Entrez Gene 13144
UniGene Mm.10294
RefSeq NM_001190473 XM_006513195 NM_001190474 NM_007828
OMIM
CCDS CCDS24045
HPRD
IMGT
MGI ID MGI:1203520
MGI Symbol Dapk3
EMBL AB007143 BC125443 BC137680 CH466553
GenPept AAI25444 AAI37681 BAA24954 EDL31449
RNA Seq Atlas 13144

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca