Mus musculus Gene: Dck
Summary
InnateDB Gene IDBG-177596.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dck
Gene Name deoxycytidine kinase
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000029366
Encoded Proteins
deoxycytidine kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000156136:
Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008]
Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:88764996-88783281
Strand Forward strand
Band E1
Transcripts
ENSMUST00000031311 ENSMUSP00000031311
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004137 deoxycytidine kinase activity
GO:0005524 ATP binding
GO:0008144 drug binding
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0042803 protein homodimerization activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006220 pyrimidine nucleotide metabolic process
GO:0009157 deoxyribonucleoside monophosphate biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0016310 phosphorylation
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Pyrimidine metabolism pathway
Purine metabolism pathway
Metabolism pathway
Pyrimidine salvage reactions pathway
Purine salvage pathway
Metabolism of nucleotides pathway
KEGG
Purine metabolism pathway
Pyrimidine metabolism pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Purine metabolism pathway
Pyrimidine salvage reactions pathway
Pyrimidine metabolism pathway
Purine salvage pathway
Metabolism of nucleotides pathway
Metabolism pathway
Pyrimidine metabolism pathway
Metabolism of nucleotides pathway
Purine metabolism pathway
Purine salvage pathway
Metabolism pathway
Pyrimidine salvage reactions pathway
KEGG
Purine metabolism pathway
Pyrimidine metabolism pathway
INOH
Pyrimidine nucleotides nucleosides metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.298892 Mm.470506
RefSeq NM_007832
OMIM
CCDS CCDS19405
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas