InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dck

Summary

InnateDB Gene

IDBG-177596.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dck

Gene Name

deoxycytidine kinase

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029366

Encoded Proteins

IDBP-177598

deoxycytidine kinase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000156136:
Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008]
Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:88764996-88783281

Strand

Forward strand

Band

Transcripts

ENSMUST00000031311

ENSMUSP00000031311

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004137	deoxycytidine kinase activity
GO:0005524	ATP binding
GO:0008144	drug binding
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0042803	protein homodimerization activity

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0006220	pyrimidine nucleotide metabolic process
GO:0009157	deoxyribonucleoside monophosphate biosynthetic process
GO:0009165	nucleotide biosynthetic process
GO:0016310	phosphorylation