Version 5.4
Homo sapiens Gene: OTUB2
Summary
InnateDB Gene IDBG-17807.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OTUB2
Gene Name OTU domain, ubiquitin aldehyde binding 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000089723
Encoded Proteins
IDBP-17809
OTU domain, ubiquitin aldehyde binding 2
IDBP-601876
OTU domain, ubiquitin aldehyde binding 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 19996094
OTUB2 and OTUB1 negatively regulate virus-triggered type I interferon (IFN) induction and cellular antiviral response by deubiquitinating TRAF3 and -6.
Entrez Gene
Summary This gene encodes one of several deubiquitylating enzymes. Ubiquitin modification of proteins is needed for their stability and function; to reverse the process, deubiquityling enzymes remove ubiquitin. This protein contains an OTU domain and binds Ubal (ubiquitin aldehyde); an active cysteine protease site is present in the OTU domain. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:94026329-94048930
Strand Forward strand
Band q32.12
Transcripts
ENST00000203664 ENSP00000203664
ENST00000553723 ENSP00000451283
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
Experimentally validated
Total 29 [view]
Protein-Protein 29 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004843 ubiquitin-specific protease activity
GO:0008242 omega peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006520 cellular amino acid metabolic process
GO:0016579 protein deubiquitination
GO:0019538 protein metabolic process
GO:0035871 protein K11-linked deubiquitination
GO:0045087 innate immune response (InnateDB)
GO:0070536 protein K63-linked deubiquitination
GO:0071108 protein K48-linked deubiquitination
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021203
View Gene Order
ENSBTAG00000014981
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.278815 Hs.599460
RefSeq NM_023112 XM_005268055 XM_006725171
HUGO
OMIM
CCDS CCDS9917
HPRD 07620
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca