Homo sapiens Gene: MATK
Summary
InnateDB Gene IDBG-17829.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MATK
Gene Name megakaryocyte-associated tyrosine kinase
Synonyms CHK; CTK; HHYLTK; HYL; HYLTK; Lsk;
Species Homo sapiens
Ensembl Gene ENSG00000007264
Encoded Proteins
megakaryocyte-associated tyrosine kinase
megakaryocyte-associated tyrosine kinase
megakaryocyte-associated tyrosine kinase
megakaryocyte-associated tyrosine kinase
megakaryocyte-associated tyrosine kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:3777970-3802129
Strand Reverse strand
Band p13.3
Transcripts
ENST00000310132 ENSP00000308734
ENST00000395045 ENSP00000378485
ENST00000395040 ENSP00000378481
ENST00000592612
ENST00000587180 ENSP00000468465
ENST00000590028 ENSP00000467006
ENST00000588983 ENSP00000465761
ENST00000585778 ENSP00000468030
ENST00000590493 ENSP00000468576
ENST00000590849 ENSP00000467992
ENST00000592300
ENST00000591059 ENSP00000465556
ENST00000590980 ENSP00000467472
ENST00000590821
ENST00000619596 ENSP00000483213
ENST00000612526 ENSP00000478847
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0007498 mesoderm development
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0018108 peptidyl-tyrosine phosphorylation
Cellular Component
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
KitReceptor pathway
REACTOME
Signal Transduction pathway
Signaling by ERBB2 pathway
KEGG
Neurotrophin signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Neurotrophic factor-mediated Trk receptor signaling
Signaling events mediated by Stem cell factor receptor (c-Kit)
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.631845
RefSeq NM_002378 NM_139354 NM_139355
HUGO
OMIM
CCDS CCDS12113 CCDS12114 CCDS42468
HPRD 02496
IMGT
EMBL
GenPept
RNA Seq Atlas