InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MATK

Summary

InnateDB Gene

IDBG-17829.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MATK

Gene Name

megakaryocyte-associated tyrosine kinase

Synonyms

CHK; CTK; HHYLTK; HYL; HYLTK; Lsk

Species

Homo sapiens

Ensembl Gene

ENSG00000007264

Encoded Proteins

IDBP-17833

megakaryocyte-associated tyrosine kinase

IDBP-240322

megakaryocyte-associated tyrosine kinase

IDBP-240324

megakaryocyte-associated tyrosine kinase

IDBP-760891

IDBP-765753

IDBP-763505

IDBP-760447

IDBP-765699

IDBP-763947

IDBP-765234

IDBP-762198

IDBP-811117

megakaryocyte-associated tyrosine kinase

IDBP-811120

megakaryocyte-associated tyrosine kinase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:3777970-3802129

Strand

Reverse strand

Band

p13.3

Transcripts

ENST00000310132	ENSP00000308734
ENST00000395045	ENSP00000378485
ENST00000395040	ENSP00000378481
ENST00000592612
ENST00000587180	ENSP00000468465
ENST00000590028	ENSP00000467006
ENST00000588983	ENSP00000465761
ENST00000585778	ENSP00000468030
ENST00000590493	ENSP00000468576
ENST00000590849	ENSP00000467992
ENST00000592300
ENST00000591059	ENSP00000465556
ENST00000590980	ENSP00000467472
ENST00000590821
ENST00000619596	ENSP00000483213
ENST00000612526	ENSP00000478847

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007498	mesoderm development
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0018108	peptidyl-tyrosine phosphorylation

Cellular Component

GO:0005829	cytosol
GO:0016020	membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000004933

View Gene Order

ENSBTAG00000006619

Not yet available

Pathways

NETPATH

NetPath_6

KitReceptor pathway

REACTOME

REACT_115755

Signaling by ERBB2 pathway

REACT_111102

Signal Transduction pathway

KEGG

hsa04722

Neurotrophin signaling pathway pathway

INOH

PID NCI

trkrpathway

Neurotrophic factor-mediated Trk receptor signaling

kitpathway

Signaling events mediated by Stem cell factor receptor (c-Kit)

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.631845

RefSeq

NM_002378 NM_139354 NM_139355

HUGO

OMIM

CCDS

CCDS12113 CCDS12114 CCDS42468

HPRD

02496

IMGT

EMBL

GenPept

RNA Seq Atlas