InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Casp7

Summary

InnateDB Gene

IDBG-178813.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Casp7

Gene Name

caspase 7

Synonyms

AI314680; caspase-7; CMH-1; ICE-IAP3; mCASP-7; Mch3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025076

Encoded Proteins

IDBP-178815

caspase 7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22807671

Host activation of Casp7 in response to pore formation during Listeria monocytogene infection represents an adaptive mechanism by which host cells can protect membrane integrity during infection.

InnateDB Annotation from Orthologs

Summary

PMID 18667412

[Homo sapiens] CASP7 is a substrate of the CASP1 inflammasomes, demonstrating the existence of a nucleotide binding and oligomerization domain-like receptor/CASP1/CASP7 cascade and the existence of distinct activation mechanisms for CASP3 and CASP7 in response to microbial stimuli and bacterial infection.

PMID 19343209

[Homo sapiens] CASP7 activation by the NLRC4 inflammasome restricts Legionella pneumophila infection in mice.

PMID 22807671

[Homo sapiens] Host activation of CASP7 in response to pore formation during Listeria monocytogene infection represents an adaptive mechanism by which host cells can protect membrane integrity during infection. (Demonstrated in mice)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165806:
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:56397129-56442344

Strand

Forward strand

Band

Transcripts

ENSMUST00000026062

ENSMUSP00000026062

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	40 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004190	aspartic-type endopeptidase activity
GO:0004197	cysteine-type endopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008234	cysteine-type peptidase activity
GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process

Biological Process

GO:0001836	release of cytochrome c from mitochondria
GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0007507	heart development
GO:0007568	aging
GO:0009411	response to UV
GO:0016485	protein processing
GO:0043525	positive regulation of neuron apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0097194	execution phase of apoptosis