Mus musculus Gene: Dyrk1a
Summary
InnateDB Gene IDBG-179036.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dyrk1a
Gene Name dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a
Synonyms 2310043O08Rik; D16Ertd272e; D16Ertd493e; Dyrk; ENSMUSG00000074897; Gm10783; mmb; Mnbh; Mp86;
Species Mus musculus
Ensembl Gene ENSMUSG00000022897
Encoded Proteins
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000157540:
This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008]
This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5\' UTR or in the 3\' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:94570010-94695517
Strand Forward strand
Band C4
Transcripts
ENSMUST00000023614 ENSMUSP00000023614
ENSMUST00000119878 ENSMUSP00000113660
ENSMUST00000122284 ENSMUSP00000112853
ENSMUST00000139250 ENSMUSP00000120344
ENSMUST00000155791 ENSMUSP00000119669
ENSMUST00000134383
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 34 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0042802 identical protein binding
GO:0043621 protein self-association
GO:0048156 tau protein binding
Biological Process
GO:0000381 regulation of alternative mRNA splicing, via spliceosome
GO:0006468 protein phosphorylation
GO:0007623 circadian rhythm
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0046777 protein autophosphorylation
GO:0090312 positive regulation of protein deacetylation
Cellular Component
GO:0005634 nucleus
GO:0016607 nuclear speck
GO:0030529 ribonucleoprotein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Cell Cycle, Mitotic pathway
G0 and Early G1 pathway
Cell Cycle pathway
Mitotic G1-G1/S phases pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
EGFR1 pathway
Hedgehog pathway
TCR pathway
REACTOME
Mitotic G1-G1/S phases pathway
Cell Cycle pathway
G0 and Early G1 pathway
Cell Cycle, Mitotic pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL A9C478
UniProt Splice Variant
Entrez Gene 13548
UniGene Mm.310973 Mm.409882 Mm.422437
RefSeq NM_001113389 NM_007890 XM_006523156 XM_006522888
OMIM
CCDS CCDS28350
HPRD
IMGT
MGI ID MGI:1330299
MGI Symbol Dyrk1a
EMBL AC165271 CT030190
GenPept
RNA Seq Atlas 13548