InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dyrk1a

Summary

InnateDB Gene

IDBG-179036.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dyrk1a

Gene Name

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a

Synonyms

2310043O08Rik; D16Ertd272e; D16Ertd493e; Dyrk; ENSMUSG00000074897; Gm10783; mmb; Mnbh; Mp86

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022897

Encoded Proteins

IDBP-179038

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a

IDBP-400794

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a

IDBP-400793

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a

IDBP-531996

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a

IDBP-537314

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000157540:
This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008]
This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5\' UTR or in the 3\' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:94570010-94695517

Strand

Forward strand

Band

Transcripts

ENSMUST00000023614	ENSMUSP00000023614
ENSMUST00000119878	ENSMUSP00000113660
ENSMUST00000122284	ENSMUSP00000112853
ENSMUST00000139250	ENSMUSP00000120344
ENSMUST00000155791	ENSMUSP00000119669
ENSMUST00000134383

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042802	identical protein binding
GO:0043621	protein self-association
GO:0048156	tau protein binding

Biological Process

GO:0000381	regulation of alternative mRNA splicing, via spliceosome
GO:0006468	protein phosphorylation
GO:0007623	circadian rhythm
GO:0018105	peptidyl-serine phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0046777	protein autophosphorylation
GO:0090312	positive regulation of protein deacetylation