Homo sapiens Gene: IRAK2
Summary
InnateDB Gene IDBG-17914.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IRAK2
Gene Name interleukin-1 receptor-associated kinase 2
Synonyms IRAK-2;
Species Homo sapiens
Ensembl Gene ENSG00000134070
Encoded Proteins
interleukin-1 receptor-associated kinase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
IRAK2 has a role in TRAF6 ubiquitination in the Toll-like receptor (TLR) pathway and thus plays a more central role than IRAK1 in TLR signalling to NFkappaB.
IRAK2 is critical in late-phase Toll-like receptor (TLR) responses, and IRAK1 and IRAK2 are essential for the initial responses to TLR stimulation.
IRAK2 is required for LPS-mediated post-transcriptional control of cytokine and chemokine expression, which plays an essential role in TLR4-induced septic shock.
IRAK2 induces cytokine and chemokine mRNA stability and translation in response to LPS stimulation in macrophages. The kinase activity of IRAK2 is required for the optimal activation of mitogen activated protein kinase signaling, which regulates cytokine/chemokine production at posttranscriptional levels.
IRAK2 is required for both TLR4 and TLR8-mediated activation of NFkB and p38 MAP kinase, and the induction of TNF mRNA. In addition, IRAK2 is required for regulating MYD88-dependent TNF-alpha mRNA stability. (Phenotype was not observed in murine ortholog, Irak2)
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Irak2 regulates cytokine and chemokine mRNA stability and translation in response to LPS stimulation in macrophages. The kinase activity of Irak2 is required for the optimal activation of mitogen activated protein kinase signalling, which regulates cytokine/chemokine production at post-transcriptional levels.
Entrez Gene
Summary IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:10164865-10243743
Strand Forward strand
Band p25.3
Transcripts
ENST00000256458 ENSP00000256458
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 81 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 81 [view]
Protein-Protein 78 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000187 activation of MAPK activity
GO:0001959 regulation of cytokine-mediated signaling pathway
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0006468 protein phosphorylation
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007254 JNK cascade
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034146 toll-like receptor 5 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034166 toll-like receptor 10 signaling pathway
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045087 innate immune response (InnateDB)
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051403 stress-activated MAPK cascade
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway
GO:0070498 interleukin-1-mediated signaling pathway
GO:0070555 response to interleukin-1
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0010008 endosome membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
IL1 pathway
REACTOME
MyD88 dependent cascade initiated on endosome pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
MyD88 cascade initiated on plasma membrane pathway
Cytokine Signaling in Immune system pathway
Innate Immune System pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
MAP kinase activation in TLR cascade pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
NOD1/2 Signaling Pathway pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Immune System pathway
MyD88-independent cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 pathway
Signaling by Interleukins pathway
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation pathway
Interleukin-1 signaling pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Activated TLR4 signalling pathway
activated TAK1 mediates p38 MAPK activation pathway
IRAK2 mediated activation of TAK1 complex pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
KEGG
Apoptosis pathway
Neurotrophin signaling pathway pathway
INOH
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID BIOCARTA
Signal transduction through il1r [Biocarta view]
PID NCI
Endogenous TLR signaling
Cross-References
SwissProt O43187
TrEMBL
UniProt Splice Variant
Entrez Gene 3656
UniGene Hs.449207
RefSeq NM_001570
HUGO HGNC:6113
OMIM 603304
CCDS CCDS33697
HPRD
IMGT
EMBL AF026273 AJ496794 AK299033 BC125184
GenPept AAB87669 AAI25185 BAG61108 CAD43180
RNA Seq Atlas 3656