InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hsd17b10

Summary

InnateDB Gene

IDBG-179843.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hsd17b10

Gene Name

hydroxysteroid (17-beta) dehydrogenase 10

Synonyms

17bHSD10; Ads9; ERAB; Hadh2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025260

Encoded Proteins

IDBP-179845

hydroxysteroid (17-beta) dehydrogenase 10

IDBP-255633

hydroxysteroid (17-beta) dehydrogenase 10

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000072506:
This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids, alcohols, and steroids. The protein has been implicated in the development of Alzheimer's disease, and mutations in the gene are the cause of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (MHBD). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]
This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids and steroids, and is a subunit of mitochondrial ribonuclease P, which is involved in tRNA maturation. The protein has been implicated in the development of Alzheimer disease, and mutations in the gene are the cause of 17beta-hydroxysteroid dehydrogenase type 10 (HSD10) deficiency. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Aug 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:152001845-152004442

Strand

Forward strand

Band

Transcripts

ENSMUST00000026289	ENSMUSP00000026289
ENSMUST00000112617	ENSMUSP00000108236
ENSMUST00000151200
ENSMUST00000140804

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0044822	poly(A) RNA binding