Mus musculus Gene: Rho
Summary
InnateDB Gene IDBG-179854.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rho
Gene Name rhodopsin
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000030324
Encoded Proteins
rhodopsin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163914:
Retinitis pigmentosa is an inherited progressive disease which is a major cause of blindness in western communities. It can be inherited as an autosomal dominant, autosomal recessive, or X-linked recessive disorder. In the autosomal dominant form,which comprises about 25% of total cases, approximately 30% of families have mutations in the gene encoding the rod photoreceptor-specific protein rhodopsin. This is the transmembrane protein which, when photoexcited, initiates the visual transduction cascade. Defects in this gene are also one of the causes of congenital stationary night blindness. [provided by RefSeq, Jul 2008]
Retinitis pigmentosa is an inherited progressive disease which is a major cause of blindness in western communities. It can be inherited as an autosomal dominant, autosomal recessive, or X-linked recessive disorder. In the autosomal dominant form,which comprises about 25%% of total cases, approximately 30%% of families have mutations in the gene encoding the rod photoreceptor-specific protein rhodopsin. This is the transmembrane protein which, when photoexcited, initiates the visual transduction cascade. Defects in this gene are also one of the causes of congenital stationary night blindness. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:115931927-115938829
Strand Forward strand
Band E3
Transcripts
ENSMUST00000032471 ENSMUSP00000032471
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
GO:0009881 photoreceptor activity
GO:0016918 retinal binding
GO:0030507 spectrin binding
GO:0046872 metal ion binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007601 visual perception
GO:0007602 phototransduction
GO:0009416 response to light stimulus
GO:0009583 detection of light stimulus
GO:0009585 red, far-red light phototransduction
GO:0016056 rhodopsin mediated signaling pathway
GO:0018298 protein-chromophore linkage
GO:0050953 sensory perception of light stimulus
GO:0060041 retina development in camera-type eye
GO:0071482 cellular response to light stimulus
Cellular Component
GO:0001750 photoreceptor outer segment
GO:0001917 photoreceptor inner segment
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0016021 integral component of membrane
GO:0030867 rough endoplasmic reticulum membrane
GO:0042622 photoreceptor outer segment membrane
GO:0060342 photoreceptor inner segment membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
GPCR downstream signaling pathway
Disease pathway
Signaling by GPCR pathway
Class A/1 (Rhodopsin-like receptors) pathway
Opsins pathway
GPCR ligand binding pathway
G alpha (i) signalling events pathway
The canonical retinoid cycle in rods (twilight vision) pathway
Visual phototransduction pathway
Inactivation, recovery and regulation of the phototransduction cascade pathway
The phototransduction cascade pathway
Signal Transduction pathway
Diseases associated with visual transduction pathway
Activation of the phototransduction cascade pathway
KEGG
Phototransduction pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Class A/1 (Rhodopsin-like receptors) pathway
Activation of the phototransduction cascade pathway
Signaling by GPCR pathway
The canonical retinoid cycle in rods (twilight vision) pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
Diseases associated with visual transduction pathway
Opsins pathway
Visual phototransduction pathway
GPCR ligand binding pathway
The phototransduction cascade pathway
Inactivation, recovery and regulation of the phototransduction cascade pathway
Disease pathway
Signaling by GPCR pathway
The phototransduction cascade pathway
Opsins pathway
The canonical retinoid cycle in rods (twilight vision) pathway
Visual phototransduction pathway
G alpha (i) signalling events pathway
Activation of the phototransduction cascade pathway
Signal Transduction pathway
Diseases associated with visual transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
Class A/1 (Rhodopsin-like receptors) pathway
Disease pathway
Inactivation, recovery and regulation of the phototransduction cascade pathway
KEGG
Phototransduction pathway
INOH
PID BIOCARTA
Visual signal transduction [Biocarta view]
PID NCI
Visual signal transduction: Rods
Cross-References
SwissProt P15409
TrEMBL
UniProt Splice Variant
Entrez Gene 212541
UniGene Mm.2965 Mm.472396
RefSeq NM_145383 XM_006505860 XM_006505861
OMIM
CCDS CCDS20446
HPRD
IMGT
MGI ID MGI:97914
MGI Symbol Rho
EMBL AK044333 AK044412 BC013125 BC031766 CH466523 M36695 M36696 M36697 M36698 M36699 M55171
GenPept AAA39861 AAA63392 AAH13125 AAH31766 BAC31871 BAC31908 EDK99545
RNA Seq Atlas 212541