InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ercc8

Summary

InnateDB Gene

IDBG-181454.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ercc8

Gene Name

excision repaiross-complementing rodent repair deficiency, complementation group 8

Synonyms

2410022P04Rik; 2810431L23Rik; 4631412O06Rik; B130065P18Rik; Ckn1; Csa

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021694

Encoded Proteins

IDBP-181456

excision repaiross-complementing rodent repair deficiency, complementation group 8

IDBP-400644

excision repaiross-complementing rodent repair deficiency, complementation group 8

IDBP-535286

excision repaiross-complementing rodent repair deficiency, complementation group 8

IDBP-538208

excision repaiross-complementing rodent repair deficiency, complementation group 8

IDBP-535064

excision repaiross-complementing rodent repair deficiency, complementation group 8

IDBP-532681

excision repaiross-complementing rodent repair deficiency, complementation group 8

IDBP-535255

excision repaiross-complementing rodent repair deficiency, complementation group 8

IDBP-539932

excision repaiross-complementing rodent repair deficiency, complementation group 8

IDBP-534039

excision repaiross-complementing rodent repair deficiency, complementation group 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000049167:
This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes. [provided by RefSeq, Jul 2008]
This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:108158731-108195364

Strand

Forward strand

Band

D2.1

Transcripts

ENSMUST00000054835	ENSMUSP00000059211
ENSMUST00000120672	ENSMUSP00000112746
ENSMUST00000123657	ENSMUSP00000117492
ENSMUST00000129117	ENSMUSP00000116507
ENSMUST00000137425
ENSMUST00000152634	ENSMUSP00000122802
ENSMUST00000142931	ENSMUSP00000118154
ENSMUST00000123182	ENSMUSP00000121777
ENSMUST00000133957	ENSMUSP00000116226
ENSMUST00000123138	ENSMUSP00000119212

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0032403	protein complex binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0006283	transcription-coupled nucleotide-excision repair
GO:0006289	nucleotide-excision repair
GO:0006974	cellular response to DNA damage stimulus
GO:0006979	response to oxidative stress
GO:0009411	response to UV
GO:0010165	response to X-ray
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045739	positive regulation of DNA repair
GO:0051865	protein autoubiquitination

Cellular Component

GO:0000109	nucleotide-excision repair complex
GO:0005634	nucleus
GO:0016363	nuclear matrix
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex
GO:0043234	protein complex