Mus musculus Gene: Herpud1 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-182026.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Herpud1 | ||||||||||||||||||||||
Gene Name | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | ||||||||||||||||||||||
Synonyms | Herp; Mifl; SUP | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000031770 | ||||||||||||||||||||||
Encoded Proteins |
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000051108:
The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. The full-length nature of all transcript variants has not been determined. [provided by RefSeq, Jan 2013] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 8:94386438-94395377 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | C5 | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Unfolded Protein Response (UPR) pathway
Metabolism of proteins pathway
PERK regulates gene expression pathway
ATF4 activates genes pathway
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KEGG |
Protein processing in endoplasmic reticulum pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
ATF4 activates genes pathway
PERK regulates gene expression pathway
Unfolded Protein Response (UPR) pathway
Metabolism of proteins pathway
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KEGG |
Protein processing in endoplasmic reticulum pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q9JJK5 | ||||||||||||||||||||||
TrEMBL | Q3TMN9 Q6A0E4 Q8C4N0 Q921B3 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 64209 | ||||||||||||||||||||||
UniGene | Mm.29151 Mm.395086 | ||||||||||||||||||||||
RefSeq | NM_022331 XM_006531260 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS22541 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | MGI:1927406 | ||||||||||||||||||||||
MGI Symbol | Herpud1 | ||||||||||||||||||||||
EMBL | AB034991 AC128663 AJ320519 AK081688 AK159500 AK165832 AK172874 CH466525 | ||||||||||||||||||||||
GenPept | BAB07892 BAC38293 BAD32152 BAE35133 BAE38402 CAC48391 EDL11127 | ||||||||||||||||||||||
RNA Seq Atlas | 64209 | ||||||||||||||||||||||