InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Phka2

Summary

InnateDB Gene

IDBG-182869.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Phka2

Gene Name

phosphorylase kinase alpha 2

Synonyms

6330505C01Rik; D330034O08; Phk

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031295

Encoded Proteins

IDBP-182871

phosphorylase kinase alpha 2

IDBP-256107

phosphorylase kinase alpha 2

IDBP-256109

phosphorylase kinase alpha 2

IDBP-256111

phosphorylase kinase alpha 2

IDBP-541385

phosphorylase kinase alpha 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000044446:
Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, and the hepatic isoform is encoded by this gene. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, which are encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9A, also known as X-linked liver glycogenosis. Alternatively spliced transcript variants have been reported, but the full-length nature of these variants has not been determined.[provided by RefSeq, Feb 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:160502166-160598878

Strand

Forward strand

Band

Transcripts

ENSMUST00000033652	ENSMUSP00000033652
ENSMUST00000112380	ENSMUSP00000107999
ENSMUST00000112377	ENSMUSP00000107996
ENSMUST00000112376	ENSMUSP00000107995
ENSMUST00000139587	ENSMUSP00000118575
ENSMUST00000146752
ENSMUST00000131765
ENSMUST00000154142
ENSMUST00000139496
ENSMUST00000153907

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004689	phosphorylase kinase activity
GO:0005516	calmodulin binding