Version 5.4
Homo sapiens Gene: HTRA4
Summary
InnateDB Gene IDBG-18301.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HTRA4
Gene Name HtrA serine peptidase 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000169495
Encoded Proteins
IDBP-18303
HtrA serine peptidase 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the HtrA family of proteases. The encoded protein contains a putative signal peptide, an insulin growth factor binding domain, a Kazal protease inhibitor domain, a conserved trypsin domain and a PDZ domain. Based on studies on other related family members, this enzyme may function as a secreted oligomeric chaperone protease to degrade misfolded secretory proteins. Other human HtrA proteins have been implicated in arthritis, tumor suppression, unfolded stress response, apoptosis, and aging. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:38974164-38988662
Strand Forward strand
Band p11.22
Transcripts
ENST00000302495 ENSP00000305919
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004175 endopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0005520 insulin-like growth factor binding
Biological Process
GO:0001558 regulation of cell growth
GO:0006508 proteolysis
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037406
View Gene Order
ENSBTAG00000019532
Not yet available
Cross-References
SwissProt P83105
TrEMBL B4DTF7
UniProt Splice Variant
Entrez Gene 203100
UniGene Hs.661014
RefSeq NM_153692
HUGO HGNC:26909
OMIM 610700
CCDS CCDS6110
HPRD
IMGT
EMBL AC108863 AK075205 AK300197 BC057765
GenPept AAH57765 BAC11470 BAG61969
RNA Seq Atlas 203100

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca