Version 5.4
Mus musculus Gene: Mapk7
Summary
InnateDB Gene IDBG-183076.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mapk7
Gene Name mitogen-activated protein kinase 7
Synonyms BMK-1; BMK1; ERK-5; ERK5; Erk5-T; PRKM7
Species Mus musculus
Ensembl Gene ENSMUSG00000001034
Encoded Proteins
IDBP-183078
mitogen-activated protein kinase 7
IDBP-183084
mitogen-activated protein kinase 7
IDBP-263951
mitogen-activated protein kinase 7
IDBP-542224
mitogen-activated protein kinase 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166484:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:61488812-61494406
Strand Reverse strand
Band B2
Transcripts
ENSMUST00000079080 ENSMUSP00000078087
ENSMUST00000101085 ENSMUSP00000098646
ENSMUST00000108714 ENSMUSP00000104354
ENSMUST00000152755
ENSMUST00000125840
ENSMUST00000128478
ENSMUST00000153441 ENSMUSP00000116084
ENSMUST00000126495
ENSMUST00000129272
ENSMUST00000139663
ENSMUST00000135521
ENSMUST00000139932
ENSMUST00000123360
ENSMUST00000140779
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004707 MAP kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0051019 mitogen-activated protein kinase binding
Biological Process
GO:0000165 MAPK cascade
GO:0006468 protein phosphorylation
GO:0007049 cell cycle
GO:0018105 peptidyl-serine phosphorylation
GO:0030154 cell differentiation
GO:0034115 negative regulation of heterotypic cell-cell adhesion
GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress
GO:0043066 negative regulation of apoptotic process
GO:0045765 regulation of angiogenesis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051247 positive regulation of protein metabolic process
GO:0051534 negative regulation of NFAT protein import into nucleus
GO:0060761 negative regulation of response to cytokine stimulus
GO:0070301 cellular response to hydrogen peroxide
GO:0071363 cellular response to growth factor stimulus
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:2000352 negative regulation of endothelial cell apoptotic process
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016605 PML body
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000166484
View Gene Order
ENSBTAG00000001014
Not yet available
Pathways
NETPATH
REACTOME
REACT_263316
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_229712
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_263004
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_239142
Innate Immune System pathway
REACT_210065
MAPK targets/ Nuclear events mediated by MAP kinases pathway
REACT_210064
ERKs are inactivated pathway
REACT_254215
Signaling by GPCR pathway
REACT_188957
Cellular responses to stress pathway
REACT_245896
MyD88 cascade initiated on plasma membrane pathway
REACT_215063
ERK/MAPK targets pathway
REACT_188573
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_255939
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_262171
MAP kinase activation in TLR cascade pathway
REACT_230745
Immune System pathway
REACT_260773
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_254406
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_216232
Signalling to ERK5 pathway
REACT_188820
Cellular Senescence pathway
REACT_249409
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_251547
Toll-Like Receptors Cascades pathway
REACT_256727
MyD88 dependent cascade initiated on endosome pathway
REACT_206033
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_248921
Signalling by NGF pathway
REACT_262462
Activated TLR4 signalling pathway
REACT_237883
NGF signalling via TRKA from the plasma membrane pathway
REACT_241786
MyD88-independent cascade pathway
REACT_188257
Signal Transduction pathway
REACT_242921
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_230045
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_238546
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_222431
Nuclear Events (kinase and transcription factor activation) pathway
REACT_261340
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_246719
Toll Like Receptor 4 (TLR4) Cascade pathway
KEGG
mmu04540
Gap junction pathway
mmu04912
GnRH signaling pathway pathway
mmu04010
MAPK signaling pathway pathway
mmu04722
Neurotrophin signaling pathway pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
INOH website
TGF-beta signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_11
TCR pathway
NetPath_56
Prolactin pathway
REACTOME
REACT_12436
ERKs are inactivated pathway
REACT_12599
ERK/MAPK targets pathway
REACT_6809
MyD88-independent cascade pathway
REACT_6783
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_6788
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_8005
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_8006
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_25024
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_25222
MyD88 dependent cascade initiated on endosome pathway
REACT_9047
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_27215
MyD88 cascade initiated on plasma membrane pathway
REACT_9027
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_9061
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_12020
Signalling to ERK5 pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_120956
Cellular responses to stress pathway
REACT_11061
Signalling by NGF pathway
REACT_9020
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_14797
Signaling by GPCR pathway
REACT_6802
Innate Immune System pathway
REACT_7980
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_111102
Signal Transduction pathway
REACT_21308
MAP kinase activation in TLR cascade pathway
REACT_6900
Immune System pathway
REACT_169274
Cellular Senescence pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_12433
Nuclear Events (kinase and transcription factor activation) pathway
REACT_169168
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_21328
MAPK targets/ Nuclear events mediated by MAP kinases pathway
REACT_25281
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_220398
ERKs are inactivated pathway
REACT_218237
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_210286
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_205036
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_224703
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_205369
Signaling by GPCR pathway
REACT_205566
Activated TLR4 signalling pathway
REACT_222278
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_224546
MyD88-independent cascade pathway
REACT_217035
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_227345
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_210224
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_206069
Cellular responses to stress pathway
REACT_213138
Immune System pathway
REACT_227036
MAP kinase activation in TLR cascade pathway
REACT_219220
Toll-Like Receptors Cascades pathway
REACT_214353
Signal Transduction pathway
REACT_210416
Nuclear Events (kinase and transcription factor activation) pathway
REACT_215025
Cellular Senescence pathway
REACT_223848
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_225653
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_207949
NGF signalling via TRKA from the plasma membrane pathway
REACT_218091
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_207066
Signalling by NGF pathway
REACT_226850
ERK/MAPK targets pathway
REACT_216676
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_219586
MyD88 dependent cascade initiated on endosome pathway
REACT_216456
MAPK targets/ Nuclear events mediated by MAP kinases pathway
REACT_216714
Innate Immune System pathway
REACT_203215
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_211704
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_217527
MyD88 cascade initiated on plasma membrane pathway
REACT_227858
Signalling to ERK5 pathway
KEGG
hsa04912
GnRH signaling pathway pathway
hsa04540
Gap junction pathway
hsa04010
MAPK signaling pathway pathway
hsa04722
Neurotrophin signaling pathway pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
INOH website
TGF-beta signaling pathway
PID NCI
mapktrkpathway
Trk receptor signaling mediated by the MAPK pathway
erbb1_downstream_pathway
ErbB1 downstream signaling
Cross-References
SwissProt Q9WVS8
TrEMBL
UniProt Splice Variant
Entrez Gene 23939
UniGene Mm.38172
RefSeq NM_001291034 NM_011841 XM_006533277 XM_006533278 NM_001291033 NM_001291037 XM_006533279
OMIM
CCDS CCDS24814 CCDS70205
HPRD
IMGT
MGI ID MGI:1346347
MGI Symbol Mapk7
EMBL AB019373 AF126159 AF126160 AF126161 AK148119 AK155187 AL604029 AY534740 BC100398
GenPept AAD39394 AAD39395 AAD39396 AAI00399 AAS38576 BAA82039 BAE28357 BAE33103 CAI24182 CAI24184 CAI24185
RNA Seq Atlas 23939

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca