Version 5.4
Mus musculus Gene: Pcdh8
Summary
InnateDB Gene IDBG-183100.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pcdh8
Gene Name protocadherin 8
Synonyms 1700080P15Rik; Papc
Species Mus musculus
Ensembl Gene ENSMUSG00000036422
Encoded Proteins
IDBP-183102
protocadherin 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes a type I transmembrane protein composed of an extracellular domain including 6 cadherin ectodomains, a single-pass transmembrane domain and a cytoplasmic tail. Unlike classical cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons with the first large exon encoding the extracellular and transmembrane region. Although this gene product is capable of homophilic interaction, it appears to affect cell-cell adhesion indirectly by initiating signaling events that regulate classical cadherin-mediated adhesion. Based on studies on this protein and its orthologs, this protocadherin mainly functions in developing embryos and the central nervous system, but can also function as a tumor suppressor. Alternative splicing yielding isoforms with unique cytoplasmic tails has been reported. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:79766772-79771312
Strand Reverse strand
Band D3
Transcripts
ENSMUST00000039568 ENSMUSP00000045333
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
Biological Process
GO:0001756 somitogenesis
GO:0007156 homophilic cell adhesion
GO:0007268 synaptic transmission
GO:0016331 morphogenesis of embryonic epithelium
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0030054 cell junction
GO:0030425 dendrite
GO:0042734 presynaptic membrane
GO:0045211 postsynaptic membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000136099
View Gene Order
ENSBTAG00000018179
Not yet available
Cross-References
SwissProt Q7TSK3
TrEMBL
UniProt Splice Variant
Entrez Gene 18530
UniGene
RefSeq NM_001042726 NM_021543
OMIM
CCDS CCDS27303
HPRD
IMGT
MGI ID MGI:1306800
MGI Symbol Pcdh8
EMBL AF231125 AK048638 BC052388 BC053008 CH466535
GenPept AAF63319 AAH52388 AAH53008 BAC33404 EDL35755
RNA Seq Atlas 18530

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca