|Mus musculus Gene: Pcdh8|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||protocadherin 8|
|Useful resources||Stemformatics EHFPI ImmGen|
This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes a type I transmembrane protein composed of an extracellular domain including 6 cadherin ectodomains, a single-pass transmembrane domain and a cytoplasmic tail. Unlike classical cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons with the first large exon encoding the extracellular and transmembrane region. Although this gene product is capable of homophilic interaction, it appears to affect cell-cell adhesion indirectly by initiating signaling events that regulate classical cadherin-mediated adhesion. Based on studies on this protein and its orthologs, this protocadherin mainly functions in developing embryos and the central nervous system, but can also function as a tumor suppressor. Alternative splicing yielding isoforms with unique cytoplasmic tails has been reported. [provided by RefSeq, Sep 2009]
|Genomic Location||Chromosome 14:79766772-79771312|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
|UniProt Splice Variant|
|EMBL||AF231125 AK048638 BC052388 BC053008 CH466535|
|GenPept||AAF63319 AAH52388 AAH53008 BAC33404 EDL35755|
|RNA Seq Atlas||18530|