Version 5.4
Mus musculus Gene: Grap
Summary
InnateDB Gene IDBG-183413.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Grap
Gene Name GRB2-related adaptor protein
Synonyms 8430435N19Rik; BB233594
Species Mus musculus
Ensembl Gene ENSMUSG00000004837
Encoded Proteins
IDBP-183415
GRB2-related adaptor protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000154016:
This gene encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. In general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:61653265-61672784
Strand Forward strand
Band B2
Transcripts
ENSMUST00000004959 ENSMUSP00000004959
ENSMUST00000155380
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000154016
View Gene Order
ENSBTAG00000003707
Not yet available
Pathways
NETPATH
REACTOME
REACT_188578
Signaling by SCF-KIT pathway
REACT_188257
Signal Transduction pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_6
KitReceptor pathway
NetPath_11
TCR pathway
REACTOME
REACT_111040
Signaling by SCF-KIT pathway
REACT_111102
Signal Transduction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_027817
OMIM
CCDS CCDS24817
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca