Version 5.4
Homo sapiens Gene: ADAM9
Summary
InnateDB Gene IDBG-18369.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADAM9
Gene Name ADAM metallopeptidase domain 9
Synonyms CORD9; MCMP; MDC9; Mltng
Species Homo sapiens
Ensembl Gene ENSG00000168615
Encoded Proteins
IDBP-18371
ADAM metallopeptidase domain 9
IDBP-477774
ADAM metallopeptidase domain 9
IDBP-474127
ADAM metallopeptidase domain 9
IDBP-475819
ADAM metallopeptidase domain 9
IDBP-479133
ADAM metallopeptidase domain 9
IDBP-484424
ADAM metallopeptidase domain 9
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:38996869-39105144
Strand Forward strand
Band p11.22
Transcripts
ENST00000379917 ENSP00000369249
ENST00000466936 ENSP00000420257
ENST00000481513 ENSP00000417066
ENST00000487273 ENSP00000419446
ENST00000481873 ENSP00000418437
ENST00000468065 ENSP00000418737
ENST00000481058
ENST00000484143
ENST00000463437
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0005080 protein kinase C binding
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005518 collagen binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0017124 SH3 domain binding
GO:0043236 laminin binding
Biological Process
GO:0000186 activation of MAPKK activity
GO:0006508 proteolysis
GO:0006509 membrane protein ectodomain proteolysis
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0010042 response to manganese ion
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0030216 keratinocyte differentiation
GO:0030574 collagen catabolic process
GO:0033627 cell adhesion mediated by integrin
GO:0033630 positive regulation of cell adhesion mediated by integrin
GO:0033631 cell-cell adhesion mediated by integrin
GO:0034241 positive regulation of macrophage fusion
GO:0034612 response to tumor necrosis factor
GO:0034616 response to laminar fluid shear stress
GO:0042117 monocyte activation
GO:0042542 response to hydrogen peroxide
GO:0050714 positive regulation of protein secretion
GO:0051044 positive regulation of membrane protein ectodomain proteolysis
GO:0051088 PMA-inducible membrane protein ectodomain proteolysis
GO:0051384 response to glucocorticoid
GO:0051549 positive regulation of keratinocyte migration
GO:0051592 response to calcium ion
GO:0071222 cellular response to lipopolysaccharide
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0031233 intrinsic to external side of plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031555
View Gene Order
ENSBTAG00000017455
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_11
TCR pathway
REACTOME
REACT_150401
Collagen degradation pathway
REACT_118779
Extracellular matrix organization pathway
REACT_118572
Degradation of the extracellular matrix pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.2442 Hs.591852 Hs.618683
RefSeq NM_003816
HUGO
OMIM
CCDS CCDS6112
HPRD 04091
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca