Mus musculus Gene: Cited4
Summary
InnateDB Gene IDBG-183812.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cited4
Gene Name Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
Synonyms MRG-2; Mrg2;
Species Mus musculus
Ensembl Gene ENSMUSG00000070803
Encoded Proteins
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000179862:
The protein encoded by this intronless gene belongs to the CITED family of transcriptional coactivators that bind to several proteins, including CREB-binding protein (CBP) and p300, via a conserved 32 aa C-terminal motif, and regulate gene transcription. This protein also interacts with transcription factor AP2 (TFAP2), and thus may function as a co-activator for TFAP2. Hypermethylation and transcriptional downregulation of this gene has been observed in oligodendroglial tumors with deletions of chromosomal arms 1p and 19q, and associated with longer recurrence-free and overall survival of patients with oligodendroglial tumors. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:120666572-120667820
Strand Forward strand
Band D2.2
Transcripts
ENSMUST00000094814 ENSMUSP00000092408
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0043627 response to estrogen
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q9WUL8
TrEMBL A2A7E7
UniProt Splice Variant
Entrez Gene 56222
UniGene Mm.272646
RefSeq NM_019563
OMIM
CCDS CCDS18592
HPRD
IMGT
MGI ID MGI:1861694
MGI Symbol Cited4
EMBL AF143369 AK012136 AK154030 BC025116 BC080723 BC132360 BC132362 CH466552
GenPept AAD37357 AAH25116 AAH80723 AAI32361 AAI32363 BAB28054 BAE32327 EDL30419
RNA Seq Atlas 56222