InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Runx2

Summary

InnateDB Gene

IDBG-184938.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Runx2

Gene Name

runt related transcription factor 2

Synonyms

AML3; Cbf; Cbfa-1; Cbfa1; LS3; Osf2; Pebp2a1; PEBP2aA; Pebpa2a

Species

Mus musculus

Ensembl Gene

ENSMUSG00000039153

Encoded Proteins

IDBP-253591

runt related transcription factor 2

IDBP-253593

runt related transcription factor 2

IDBP-253595

runt related transcription factor 2

IDBP-535754

runt related transcription factor 2

IDBP-538502

runt related transcription factor 2

IDBP-538365

runt related transcription factor 2

IDBP-538719

runt related transcription factor 2

IDBP-535298

runt related transcription factor 2

IDBP-532060

runt related transcription factor 2

IDBP-540341

runt related transcription factor 2

IDBP-537494

runt related transcription factor 2

IDBP-537292

runt related transcription factor 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000124813:
This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:44495987-44814797

Strand

Reverse strand

Band

Transcripts

ENSMUST00000113572	ENSMUSP00000109202
ENSMUST00000113571	ENSMUSP00000109201
ENSMUST00000113568	ENSMUSP00000109198
ENSMUST00000162816	ENSMUSP00000125498
ENSMUST00000162878	ENSMUSP00000123707
ENSMUST00000159943	ENSMUSP00000124918
ENSMUST00000162629	ENSMUSP00000124374
ENSMUST00000162373	ENSMUSP00000124494
ENSMUST00000160673	ENSMUSP00000123743
ENSMUST00000162130	ENSMUSP00000124199
ENSMUST00000160199	ENSMUSP00000125196
ENSMUST00000160672	ENSMUSP00000125284
ENSMUST00000161489

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.

Experimentally validated
Total	37 [view]
Protein-Protein	32 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	46 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001104	RNA polymerase II transcription cofactor activity
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019904	protein domain specific binding
GO:0043425	bHLH transcription factor binding
GO:0044212	transcription regulatory region DNA binding
GO:0070491	repressing transcription factor binding

Biological Process

GO:0001501	skeletal system development
GO:0001649	osteoblast differentiation
GO:0001958	endochondral ossification
GO:0002051	osteoblast fate commitment
GO:0002062	chondrocyte differentiation
GO:0002063	chondrocyte development
GO:0002076	osteoblast development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0008284	positive regulation of cell proliferation
GO:0030217	T cell differentiation
GO:0030278	regulation of ossification
GO:0030509	BMP signaling pathway
GO:0032332	positive regulation of chondrocyte differentiation
GO:0035115	embryonic forelimb morphogenesis
GO:0040036	regulation of fibroblast growth factor receptor signaling pathway
GO:0042475	odontogenesis of dentin-containing tooth
GO:0042487	regulation of odontogenesis of dentin-containing tooth
GO:0045667	regulation of osteoblast differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0045879	negative regulation of smoothened signaling pathway
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048469	cell maturation
GO:0048701	embryonic cranial skeleton morphogenesis
GO:0048705	skeletal system morphogenesis
GO:0048863	stem cell differentiation
GO:0071773	cellular response to BMP stimulus
GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus