Homo sapiens Gene: GSC
Summary
InnateDB Gene IDBG-18496.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GSC
Gene Name goosecoid homeobox
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000133937
Encoded Proteins
goosecoid homeobox
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the bicoid subfamily of the paired (PRD) homeobox family of proteins. The encoded protein acts as a transcription factor and may be autoregulatory. A similar protein in mice plays a role in craniofacial and rib cage development during embryogenesis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:94768216-94770230
Strand Reverse strand
Band q32.13
Transcripts
ENST00000238558 ENSP00000238558
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001085 RNA polymerase II transcription factor binding
GO:0001103 RNA polymerase II repressing transcription factor binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0007369 gastrulation
GO:0009653 anatomical structure morphogenesis
GO:0014036 neural crest cell fate specification
GO:0021904 dorsal/ventral neural tube patterning
GO:0023019 signal transduction involved in regulation of gene expression
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030900 forebrain development
GO:0042474 middle ear morphogenesis
GO:0043583 ear development
GO:0048644 muscle organ morphogenesis
GO:0048704 embryonic skeletal system morphogenesis
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Regulation of retinoblastoma protein
Regulation of nuclear SMAD2/3 signaling
Cross-References
SwissProt P56915
TrEMBL
UniProt Splice Variant
Entrez Gene 145258
UniGene
RefSeq NM_173849
HUGO HGNC:4612
OMIM 138890
CCDS CCDS9930
HPRD
IMGT
EMBL AY177407 BC063580
GenPept AAH63580 AAO18645
RNA Seq Atlas 145258