Mus musculus Gene: Cdc5l
Summary
InnateDB Gene IDBG-185058.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cdc5l
Gene Name cell division cycle 5-like (S. pombe)
Synonyms 1200002I02Rik; AA408004; PCDC5RP;
Species Mus musculus
Ensembl Gene ENSMUSG00000023932
Encoded Proteins
cell division cycle 5-like (S. pombe)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000096401:
The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:45391892-45433707
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000024727 ENSMUSP00000024727
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 136 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 25 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 136 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0019904 protein domain specific binding
GO:0044822 poly(A) RNA binding
GO:0071987 WD40-repeat domain binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007049 cell cycle
GO:0008380 RNA splicing
Cellular Component
GO:0000974 Prp19 complex
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0016607 nuclear speck
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
mRNA Splicing pathway
Gene Expression pathway
mRNA Splicing - Major Pathway pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
KEGG
Spliceosome pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Processing of Capped Intron-Containing Pre-mRNA pathway
mRNA Splicing pathway
Gene Expression pathway
mRNA Splicing - Major Pathway pathway
mRNA Splicing - Major Pathway pathway
mRNA Splicing pathway
Gene Expression pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
KEGG
Spliceosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q6A068
TrEMBL Q3UCF2
UniProt Splice Variant
Entrez Gene 71702
UniGene Mm.28270 Mm.455701 Mm.482553 Mm.490427 Mm.490446
RefSeq NM_152810 XM_006514403 XM_006514404 XM_006514405 XM_006514406 XM_006514407 XM_006514408 XM_006514409 XM_006514410
OMIM
CCDS CCDS37627
HPRD
IMGT
MGI ID MGI:1918952
MGI Symbol Cdc5l
EMBL AK146892 AK150562 AK150861 AK172950 BC031480 CH466559
GenPept AAH31480 BAD32228 BAE27510 BAE29661 BAE29915 EDL23430
RNA Seq Atlas 102635357 102635473 668198 668203 668205 668209 668213 668216 71702