InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cdc5l

Summary

InnateDB Gene

IDBG-185058.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdc5l

Gene Name

cell division cycle 5-like (S. pombe)

Synonyms

1200002I02Rik; AA408004; PCDC5RP

Species

Mus musculus

Ensembl Gene

ENSMUSG00000023932

Encoded Proteins

IDBP-185060

cell division cycle 5-like (S. pombe)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000096401:
The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:45391892-45433707

Strand

Reverse strand

Band

Transcripts

ENSMUST00000024727

ENSMUSP00000024727

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 136 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	136 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0044822	poly(A) RNA binding
GO:0071987	WD40-repeat domain binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007049	cell cycle
GO:0008380	RNA splicing

Cellular Component

GO:0000974	Prp19 complex
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0016607	nuclear speck
GO:0071013	catalytic step 2 spliceosome