Version 5.4
Mus musculus Gene: Phc1
Summary
InnateDB Gene IDBG-185342.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Phc1
Gene Name polyhomeotic-like 1 (Drosophila)
Synonyms AW557034; Edr; Edr1; Mph1; Rae-28; rae28
Species Mus musculus
Ensembl Gene ENSMUSG00000040669
Encoded Proteins
IDBP-185344
polyhomeotic-like 1 (Drosophila)
IDBP-185346
polyhomeotic-like 1 (Drosophila)
IDBP-255659
polyhomeotic-like 1 (Drosophila)
IDBP-541521
polyhomeotic-like 1 (Drosophila)
IDBP-532906
polyhomeotic-like 1 (Drosophila)
IDBP-538257
polyhomeotic-like 1 (Drosophila)
IDBP-533284
polyhomeotic-like 1 (Drosophila)
IDBP-536723
polyhomeotic-like 1 (Drosophila)
IDBP-540506
polyhomeotic-like 1 (Drosophila)
IDBP-531724
polyhomeotic-like 1 (Drosophila)
IDBP-532824
polyhomeotic-like 1 (Drosophila)
IDBP-533152
polyhomeotic-like 1 (Drosophila)
IDBP-531693
polyhomeotic-like 1 (Drosophila)
IDBP-537587
polyhomeotic-like 1 (Drosophila)
IDBP-539344
polyhomeotic-like 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111752:
This gene is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. The gene product is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMH1. The gene product, the EDR2 protein, and the Drosophila polyhomeotic protein share 2 highly conserved domains, named homology domains I and II. These domains are involved in protein-protein interactions and may mediate heterodimerization of the protein encoded by this gene and the EDR2 protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:122317731-122340561
Strand Reverse strand
Band F1
Transcripts
ENSMUST00000079560 ENSMUSP00000078514
ENSMUST00000081849 ENSMUSP00000080532
ENSMUST00000112600 ENSMUSP00000108219
ENSMUST00000161739 ENSMUSP00000125568
ENSMUST00000160696 ENSMUSP00000125580
ENSMUST00000159252 ENSMUSP00000124678
ENSMUST00000161054 ENSMUSP00000123911
ENSMUST00000160163 ENSMUSP00000125545
ENSMUST00000161877 ENSMUSP00000123854
ENSMUST00000161290 ENSMUSP00000125110
ENSMUST00000160843 ENSMUSP00000125030
ENSMUST00000160863
ENSMUST00000159384 ENSMUSP00000124744
ENSMUST00000161149 ENSMUSP00000125717
ENSMUST00000159657 ENSMUSP00000123957
ENSMUST00000161210 ENSMUSP00000124795
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 19 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0016574 histone ubiquitination
GO:0071300 cellular response to retinoic acid
Cellular Component
GO:0001739 sex chromatin
GO:0005634 nucleus
GO:0016604 nuclear body
GO:0031519 PcG protein complex
GO:0035102 PRC1 complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000111752
View Gene Order
ENSBTAG00000018205
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_120956
Cellular responses to stress pathway
REACT_169274
Cellular Senescence pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E0CXA6 E0CXC9 E0CYR2 Q3TJ47 Q3V116
UniProt Splice Variant
Entrez Gene 13619
UniGene Mm.412735 Mm.6822
RefSeq NM_001042623 XM_006505500 NM_001271579 NM_007905 XM_006505498 XM_006505499
OMIM
CCDS CCDS39620 CCDS20494
HPRD
IMGT
MGI ID MGI:103248
MGI Symbol Phc1
EMBL AC153579 AK132756 AK167590
GenPept BAE21337 BAE39648
RNA Seq Atlas 13619

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca