Homo sapiens Gene: ADAM18
Summary
InnateDB Gene IDBG-18575.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADAM18
Gene Name ADAM metallopeptidase domain 18
Synonyms ADAM27; tMDCIII;
Species Homo sapiens
Ensembl Gene ENSG00000168619
Encoded Proteins
ADAM metallopeptidase domain 18
ADAM metallopeptidase domain 18
ADAM metallopeptidase domain 18
ADAM metallopeptidase domain 18
ADAM metallopeptidase domain 18
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a sperm surface protein. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:39584489-39730064
Strand Forward strand
Band p11.22
Transcripts
ENST00000379866 ENSP00000369195
ENST00000265707 ENSP00000265707
ENST00000520001 ENSP00000429335
ENST00000520772 ENSP00000429908
ENST00000520087 ENSP00000428083
ENST00000520559
ENST00000523755
ENST00000524117
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
GO:0007275 multicellular organismal development
GO:0007283 spermatogenesis
GO:0030154 cell differentiation
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.127930
RefSeq NM_001190956 NM_014237
HUGO
OMIM
CCDS CCDS55225 CCDS6113
HPRD 07469
IMGT
EMBL
GenPept
RNA Seq Atlas