Version 5.4
Mus musculus Gene: Saa3
Summary
InnateDB Gene IDBG-186336.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Saa3
Gene Name serum amyloid A 3
Synonyms AV098916; l7R3; Saa-3
Species Mus musculus
Ensembl Gene ENSMUSG00000040026
Encoded Proteins
IDBP-186338
serum amyloid A 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000173432:
This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Jun 2012]
This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer\'s disease and Crohn\'s disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:46711998-46715676
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000006956 ENSMUSP00000006956
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 1 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006953 acute-phase response
GO:0035634 response to stilbenoid
Cellular Component
GO:0005576 extracellular region
GO:0034364 high-density lipoprotein particle
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000173432
View Gene Order
Pathways
NETPATH
REACTOME
REACT_202898
TRAF6 mediated NF-kB activation pathway
REACT_263316
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_229712
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_263004
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_239142
Innate Immune System pathway
REACT_223625
GPCR downstream signaling pathway
REACT_189085
Disease pathway
REACT_254215
Signaling by GPCR pathway
REACT_261161
Class A/1 (Rhodopsin-like receptors) pathway
REACT_245896
MyD88 cascade initiated on plasma membrane pathway
REACT_198563
Amyloids pathway
REACT_188573
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_255939
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_215863
ZBP1(DAI) mediated induction of type I IFNs pathway
REACT_230745
Immune System pathway
REACT_196573
Binding and Uptake of Ligands by Scavenger Receptors pathway
REACT_260773
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_254406
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_198647
Advanced glycosylation endproduct receptor signaling pathway
REACT_249409
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_231468
GPCR ligand binding pathway
REACT_235286
Peptide ligand-binding receptors pathway
REACT_202555
DEx/H-box helicases activate type I IFN and inflammatory cytokines production pathway
REACT_251547
Toll-Like Receptors Cascades pathway
REACT_256727
MyD88 dependent cascade initiated on endosome pathway
REACT_218897
Cytosolic sensors of pathogen-associated DNA pathway
REACT_250376
G alpha (i) signalling events pathway
REACT_222971
RIP-mediated NFkB activation via ZBP1 pathway
REACT_262462
Activated TLR4 signalling pathway
REACT_207651
G alpha (q) signalling events pathway
REACT_241786
MyD88-independent cascade pathway
REACT_188257
Signal Transduction pathway
REACT_219118
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
REACT_242921
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_230045
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_238546
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_219800
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
REACT_196592
Scavenging by Class B Receptors pathway
REACT_229705
Formyl peptide receptors bind formyl peptides and many other ligands pathway
REACT_261340
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_246719
Toll Like Receptor 4 (TLR4) Cascade pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_118563
RIP-mediated NFkB activation via ZBP1 pathway
REACT_118764
ZBP1(DAI) mediated induction of type I IFNs pathway
REACT_24969
TRAF6 mediated NF-kB activation pathway
REACT_25359
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
REACT_25195
Advanced glycosylation endproduct receptor signaling pathway
REACT_21281
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
REACT_6809
MyD88-independent cascade pathway
REACT_6783
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_6788
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_8005
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_8006
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_25024
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_25222
MyD88 dependent cascade initiated on endosome pathway
REACT_9047
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_27215
MyD88 cascade initiated on plasma membrane pathway
REACT_9027
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_9061
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_19231
G alpha (i) signalling events pathway
REACT_21264
Formyl peptide receptors bind formyl peptides and many other ligands pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_75925
Amyloids pathway
REACT_9020
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_14797
Signaling by GPCR pathway
REACT_6802
Innate Immune System pathway
REACT_7980
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_160300
Binding and Uptake of Ligands by Scavenger Receptors pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_163679
Scavenging by Class B Receptors pathway
REACT_163773
DEx/H-box helicases activate type I IFN and inflammatory cytokines production pathway
REACT_6900
Immune System pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_21340
GPCR ligand binding pathway
REACT_25281
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_118823
Cytosolic sensors of pathogen-associated DNA pathway
REACT_116125
Disease pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P04918
TrEMBL V6AW78
UniProt Splice Variant
Entrez Gene 20210
UniGene
RefSeq NM_011315
OMIM
CCDS CCDS21282
HPRD
IMGT
MGI ID MGI:98223
MGI Symbol Saa3
EMBL BC055885 HG515535 M17792 M25467 X03479 X03505 X03506 X03507
GenPept AAA37231 AAA40088 AAH55885 CAA27199 CAA27219 CDI30254
RNA Seq Atlas 20210

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca