Mus musculus Gene: Saa3
Summary
InnateDB Gene IDBG-186336.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Saa3
Gene Name serum amyloid A 3
Synonyms AV098916; l7R3; Saa-3;
Species Mus musculus
Ensembl Gene ENSMUSG00000040026
Encoded Proteins
serum amyloid A 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000173432:
This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Jun 2012]
This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer\'s disease and Crohn\'s disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:46711998-46715676
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000006956 ENSMUSP00000006956
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 1 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006953 acute-phase response
GO:0035634 response to stilbenoid
Cellular Component
GO:0005576 extracellular region
GO:0034364 high-density lipoprotein particle
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
TRAF6 mediated NF-kB activation pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Innate Immune System pathway
GPCR downstream signaling pathway
Disease pathway
Signaling by GPCR pathway
Class A/1 (Rhodopsin-like receptors) pathway
MyD88 cascade initiated on plasma membrane pathway
Amyloids pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
ZBP1(DAI) mediated induction of type I IFNs pathway
Immune System pathway
Binding and Uptake of Ligands by Scavenger Receptors pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
Advanced glycosylation endproduct receptor signaling pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
GPCR ligand binding pathway
Peptide ligand-binding receptors pathway
DEx/H-box helicases activate type I IFN and inflammatory cytokines production pathway
Toll-Like Receptors Cascades pathway
MyD88 dependent cascade initiated on endosome pathway
Cytosolic sensors of pathogen-associated DNA pathway
G alpha (i) signalling events pathway
RIP-mediated NFkB activation via ZBP1 pathway
Activated TLR4 signalling pathway
G alpha (q) signalling events pathway
MyD88-independent cascade pathway
Signal Transduction pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
TRIF-mediated TLR3/TLR4 signaling pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
Scavenging by Class B Receptors pathway
Formyl peptide receptors bind formyl peptides and many other ligands pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
RIP-mediated NFkB activation via ZBP1 pathway
MyD88 dependent cascade initiated on endosome pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Class A/1 (Rhodopsin-like receptors) pathway
G alpha (q) signalling events pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
ZBP1(DAI) mediated induction of type I IFNs pathway
MyD88 cascade initiated on plasma membrane pathway
Formyl peptide receptors bind formyl peptides and many other ligands pathway
Signaling by GPCR pathway
Innate Immune System pathway
Peptide ligand-binding receptors pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
TRAF6 mediated NF-kB activation pathway
Binding and Uptake of Ligands by Scavenger Receptors pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Amyloids pathway
G alpha (i) signalling events pathway
Scavenging by Class B Receptors pathway
DEx/H-box helicases activate type I IFN and inflammatory cytokines production pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Immune System pathway
MyD88-independent cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Activated TLR4 signalling pathway
GPCR ligand binding pathway
Advanced glycosylation endproduct receptor signaling pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Cytosolic sensors of pathogen-associated DNA pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
Disease pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P04918
TrEMBL V6AW78
UniProt Splice Variant
Entrez Gene 20210
UniGene
RefSeq NM_011315
OMIM
CCDS CCDS21282
HPRD
IMGT
MGI ID MGI:98223
MGI Symbol Saa3
EMBL BC055885 HG515535 M17792 M25467 X03479 X03505 X03506 X03507
GenPept AAA37231 AAA40088 AAH55885 CAA27199 CAA27219 CDI30254
RNA Seq Atlas 20210