Version 5.4
Mus musculus Gene: Hsf4
Summary
InnateDB Gene IDBG-186991.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hsf4
Gene Name heat shock transcription factor 4
Synonyms HSF 4; HSTF 4; HSTF4; ldis1; mHSF4
Species Mus musculus
Ensembl Gene ENSMUSG00000033249
Encoded Proteins
IDBP-186993
heat shock transcription factor 4
IDBP-621878
heat shock transcription factor 4
IDBP-621880
heat shock transcription factor 4
IDBP-621881
heat shock transcription factor 4
IDBP-621882
heat shock transcription factor 4
IDBP-621884
heat shock transcription factor 4
IDBP-621886
heat shock transcription factor 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102878:
Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:105269801-105275845
Strand Forward strand
Band D3
Transcripts
ENSMUST00000036127 ENSMUSP00000048904
ENSMUST00000173640 ENSMUSP00000133532
ENSMUST00000173102 ENSMUSP00000133879
ENSMUST00000172525 ENSMUSP00000134206
ENSMUST00000174837 ENSMUSP00000134477
ENSMUST00000173859 ENSMUSP00000134213
ENSMUST00000163734 ENSMUSP00000126278
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0019903 protein phosphatase binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001654 eye development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006950 response to stress
GO:0008284 positive regulation of cell proliferation
GO:0033169 histone H3-K9 demethylation
GO:0043010 camera-type eye development
GO:0045597 positive regulation of cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048468 cell development
GO:0070207 protein homotrimerization
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000102878
View Gene Order
ENSBTAG00000003514
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.89204
RefSeq NM_001256042 NM_001256044 NM_011939 XM_006531041 XM_006531042
OMIM
CCDS CCDS57638 CCDS57639 CCDS57640
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca