Version 5.4
Mus musculus Gene: C1ra
Summary
InnateDB Gene IDBG-187030.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C1ra
Gene Name complement component 1, r subcomponent A
Synonyms AI132558; C1r; mC1rA
Species Mus musculus
Ensembl Gene ENSMUSG00000055172
Encoded Proteins
IDBP-187032
complement component 1, r subcomponent A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 11445589
[Homo sapiens] C1R is the protease that mediates activation of the classical complement C1 complex and this catalytic property is mediated by C1R C-terminal region, comprising two complement control protein (CCP) modules followed by a serine protease (SP) domain.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159403:
Gene Information
Type Protein coding
Genomic Location Chromosome 6:124512632-124523440
Strand Forward strand
Band F2
Transcripts
ENSMUST00000068593 ENSMUSP00000063707
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0006508 proteolysis
GO:0006958 complement activation, classical pathway
GO:0045087 innate immune response
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000159403
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
mmu04610
Complement and coagulation cascades pathway
mmu05322
Systemic lupus erythematosus pathway
mmu05150
Staphylococcus aureus infection pathway
mmu04145
Phagosome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04610
Complement and coagulation cascades pathway
hsa05322
Systemic lupus erythematosus pathway
hsa05150
Staphylococcus aureus infection pathway
hsa04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt Q8CG16
TrEMBL Q9CTX0
UniProt Splice Variant
Entrez Gene 50909
UniGene Mm.333375 Mm.481484
RefSeq NM_023143
OMIM
CCDS CCDS20521
HPRD
IMGT
MGI ID MGI:1355313
MGI Symbol C1ra
EMBL AF148216 AF459008 AF459009 AF459010 AF459011 AK019687 BC004637
GenPept AAG01898 AAH04637 AAO15553 BAB31836
RNA Seq Atlas 50909

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca