InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mrps15

Summary

InnateDB Gene

IDBG-187723.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mrps15

Gene Name

mitochondrial ribosomal protein S15

Synonyms

1500003E24Rik; 2410002B11Rik; Mprs15

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028861

Encoded Proteins

IDBP-187725

mitochondrial ribosomal protein S15

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116898:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S15P family. The encoded protein is more than two times the size of its E. coli counterpart, with the 12S rRNA binding sites conserved. Between human and mouse, the encoded protein is the least conserved among small subunit ribosomal proteins. Pseudogenes corresponding to this gene are found on chromosomes 15q and 19q. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:126046925-126055532

Strand

Forward strand

Band

D2.2

Transcripts

ENSMUST00000030675	ENSMUSP00000030675
ENSMUST00000138739
ENSMUST00000124614

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003735	structural constituent of ribosome
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006412	translation
GO:0008150	biological_process

Cellular Component

GO:0005622	intracellular
GO:0005739	mitochondrion
GO:0005763	mitochondrial small ribosomal subunit
GO:0005840	ribosome
GO:0031965	nuclear membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000116898

View Gene Order

ENSBTAG00000024097

Not yet available

Pathways

NETPATH

REACTOME

REACT_268789

Mitochondrial translation pathway

REACT_224594

Organelle biogenesis and maintenance pathway

REACT_270125

Mitochondrial translation elongation pathway

REACT_271096

Mitochondrial translation initiation pathway

REACT_270158

Mitochondrial translation termination pathway

KEGG

mmu03010

Ribosome pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_200751

Organelle biogenesis and maintenance pathway

REACT_267673

Mitochondrial translation pathway

REACT_267680

Mitochondrial translation initiation pathway

REACT_267602

Mitochondrial translation termination pathway

REACT_267677

Mitochondrial translation elongation pathway

KEGG

hsa03010

Ribosome pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_025544

OMIM

CCDS

CCDS18641

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas