InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Itgb7

Summary

InnateDB Gene

IDBG-188077.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Itgb7

Gene Name

integrin beta 7

Synonyms

Ly69

Species

Mus musculus

Ensembl Gene

ENSMUSG00000001281

Encoded Proteins

IDBP-188079

integrin beta 7

IDBP-542371

integrin beta 7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000139626:
This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms dimers with an alpha4 chain or an alphaE chain and plays a role in leukocyte adhesion. Dimerization with alpha4 forms a homing receptor for migration of lymphocytes to the intestinal mucosa and Peyer\'s patches. Dimerization with alphaE permits binding to the ligand epithelial cadherin, a calcium-dependent adhesion molecule. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:102215995-102231935

Strand

Reverse strand

Band

Transcripts

ENSMUST00000001327	ENSMUSP00000001327
ENSMUST00000127014	ENSMUSP00000123227

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding

Biological Process

GO:0007160	cell-matrix adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007275	multicellular organismal development
GO:0050900	leukocyte migration
GO:0072678	T cell migration