InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ctcf

Summary

InnateDB Gene

IDBG-188080.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ctcf

Gene Name

CCCTC-binding factor

Synonyms

AW108038

Species

Mus musculus

Ensembl Gene

ENSMUSG00000005698

Encoded Proteins

IDBP-188082

CCCTC-binding factor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 15670593

[Homo sapiens] CTCF regulates the transcription of the interleukin 1 receptor-associates kinase 2 (IRAK2) promoter. IRAK2 is part of a family of four IRAKs that regulate immune responsiveness to bacterial endotoxins.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102974:
This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms\' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:105636568-105682922

Strand

Forward strand

Band

Transcripts

ENSMUST00000005841	ENSMUSP00000005841
ENSMUST00000132679
ENSMUST00000128510
ENSMUST00000129388
ENSMUST00000137735
ENSMUST00000156436

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.

Experimentally validated
Total	42 [view]
Protein-Protein	32 [view]
Protein-DNA	10 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	39 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043035	chromatin insulator sequence binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006306	DNA methylation
GO:0006349	regulation of gene expression by genetic imprinting
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007059	chromosome segregation
GO:0009048	dosage compensation by inactivation of X chromosome
GO:0010216	maintenance of DNA methylation
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0016568	chromatin modification
GO:0016584	nucleosome positioning
GO:0031060	regulation of histone methylation
GO:0035065	regulation of histone acetylation
GO:0040029	regulation of gene expression, epigenetic
GO:0040030	regulation of molecular function, epigenetic
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000793	condensed chromosome
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000102974

View Gene Order

ENSBTAG00000013757

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_7

TGF_beta_Receptor pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q61164

TrEMBL

Q3USR8 Q3UYZ8 Q3UZH8

UniProt Splice Variant

Entrez Gene

13018

UniGene

Mm.269474 Mm.397215

RefSeq

NM_181322 XM_006530644 XM_006530645 XM_006530646 XM_006530647 XM_006530648

OMIM

CCDS

CCDS22606

HPRD

IMGT

MGI ID

MGI:109447

MGI Symbol

Ctcf

EMBL

AK076192 AK132514 AK133842 AK134247 AK140164 BC037456 BC046398 BC049131 BC058240 U51037

GenPept

AAC52928 AAH37456 AAH46398 AAH49131 AAH58240 BAC36245 BAE21212 BAE21879 BAE22063 BAE24263

RNA Seq Atlas

13018