InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Espl1

Summary

InnateDB Gene

IDBG-188238.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Espl1

Gene Name

extra spindle poles-like 1 (S. cerevisiae)

Synonyms

AL024103; AU045071; Cerp; ESP1; PRCE; SSE

Species

Mus musculus

Ensembl Gene

ENSMUSG00000058290

Encoded Proteins

IDBP-188240

extra spindle poles-like 1 (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135476:
Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM, Nov 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:102296293-102324356

Strand

Forward strand

Band

Transcripts

ENSMUST00000064924

ENSMUSP00000064465

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008234	cysteine-type peptidase activity

Biological Process

GO:0000070	mitotic sister chromatid segregation
GO:0000212	meiotic spindle organization
GO:0006508	proteolysis
GO:0007059	chromosome segregation
GO:0007067	mitotic nuclear division
GO:0007127	meiosis I
GO:0045143	homologous chromosome segregation