Version 5.4
Mus musculus Gene: Phip
Summary
InnateDB Gene IDBG-188252.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Phip
Gene Name pleckstrin homology domain interacting protein
Synonyms 2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11
Species Mus musculus
Ensembl Gene ENSMUSG00000032253
Encoded Proteins
IDBP-188254
pleckstrin homology domain interacting protein
IDBP-789318
pleckstrin homology domain interacting protein
IDBP-789320
pleckstrin homology domain interacting protein
IDBP-789321
pleckstrin homology domain interacting protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000146247:
PHIP binds the pleckstrin homology (PH) domain of insulin receptor substrate-1 (IRS1; MIM 147545), modulates insulin signaling, and plays a role in pancreatic beta cell growth and survival (Farhang-Fallah et al., 2000 [PubMed 11018022]; Podcheko et al., 2007 [PubMed 17636024]).[supplied by OMIM, Jun 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:82866159-82975516
Strand Reverse strand
Band E2
Transcripts
ENSMUST00000034787 ENSMUSP00000034787
ENSMUST00000190774
ENSMUST00000189209
ENSMUST00000188868
ENSMUST00000190101
ENSMUST00000190936
ENSMUST00000186089 ENSMUSP00000139678
ENSMUST00000188850
ENSMUST00000187021
ENSMUST00000190822 ENSMUSP00000139866
ENSMUST00000186099
ENSMUST00000189927
ENSMUST00000189985 ENSMUSP00000140445
ENSMUST00000190405
ENSMUST00000188828
ENSMUST00000190838
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005158 insulin receptor binding
GO:0005515 protein binding
GO:0070577 lysine-acetylated histone binding
Biological Process
GO:0006606 protein import into nucleus
GO:0007010 cytoskeleton organization
GO:0008284 positive regulation of cell proliferation
GO:0008286 insulin receptor signaling pathway
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0022604 regulation of cell morphogenesis
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0040008 regulation of growth
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000146247
View Gene Order
ENSBTAG00000024688
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001081216 XM_006511564 XM_006511565 XM_006511566 XM_006511567
OMIM
CCDS CCDS40706
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca