InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hoxc6

Summary

InnateDB Gene

IDBG-189379.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hoxc6

Gene Name

homeobox C6

Synonyms

Hox-3.3; Hox-6.1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000001661

Encoded Proteins

IDBP-189381

homeobox C6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197757:
This gene belongs to the homeobox family, members of which encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC6, is one of several HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Alternatively spliced transcript variants encoding different isoforms have been identified for HOXC6. Transcript variant two includes the shared exon, and transcript variant one includes only gene-specific exons. [provided by RefSeq, Jul 2008]
This gene belongs to the homeobox family, members of which encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC6, is one of several HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5\' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Alternatively spliced transcript variants encoding different isoforms have been identified for HOXC6. Transcript variant two includes the shared exon, and transcript variant one includes only gene-specific exons. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:102998257-103011881

Strand

Forward strand

Band

Transcripts

ENSMUST00000001711	ENSMUSP00000001711
ENSMUST00000173210
ENSMUST00000173421

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0009952	anterior/posterior pattern specification
GO:0048706	embryonic skeletal system development

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000197757

View Gene Order

ENSBTAG00000009238

Not yet available

Cross-References

SwissProt

P10629

TrEMBL

B2RUB8 Q543H4

UniProt Splice Variant

Entrez Gene

15425

UniGene

Mm.438633 Mm.486588

RefSeq

NM_010465 XM_006520469

OMIM

CCDS

CCDS27895

HPRD

IMGT

MGI ID

MGI:96197

MGI Symbol

Hoxc6

EMBL

AK050798 BC141061 CH466550 J03074 M35986 S74185 X12504 X16510 X16511 X16838

GenPept

AAA37832 AAA37854 AAB20717 AAI41062 BAC34415 CAA31022 CAA31023 CAA34517 CAA34518 CAA34737 EDL03943

RNA Seq Atlas

15425