Version 5.4
| Homo sapiens Gene: KLRC3 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-18940.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | KLRC3 | ||||||||||||||||||
| Gene Name | killer cell lectin-like receptor subfamily C, member 3 | ||||||||||||||||||
| Synonyms | NKG2-E; NKG2E | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000205810 | ||||||||||||||||||
| Encoded Proteins |
killer cell lectin-like receptor subfamily C, member 3
killer cell lectin-like receptor subfamily C, member 3
killer cell lectin-like receptor subfamily C, member 3
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. KLRC3 is a member of the NKG2 group which are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 12:10412312-10420595 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | p13.2 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
| No orthologs found for this gene | |||||||||||||||||||
| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME | |||||||||||||||||||
| KEGG |
Antigen processing and presentation pathway
Natural killer cell mediated cytotoxicity pathway
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| INOH | |||||||||||||||||||
| PID NCI |
Validated nuclear estrogen receptor alpha network
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| Cross-References | |||||||||||||||||||
| SwissProt | Q07444 | ||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 3823 | ||||||||||||||||||
| UniGene | Hs.654362 | ||||||||||||||||||
| RefSeq | NM_007333 NM_002261 | ||||||||||||||||||
| HUGO | HGNC:6376 | ||||||||||||||||||
| OMIM | 602892 | ||||||||||||||||||
| CCDS | CCDS31744 CCDS41755 | ||||||||||||||||||
| HPRD | 04203 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AC022075 AC068775 AF078550 AF350016 AF350017 AF461157 AJ001685 L14542 | ||||||||||||||||||
| GenPept | AAA16833 AAD46108 AAK83803 AAK83804 AAL65232 CAA04923 | ||||||||||||||||||
| RNA Seq Atlas | 3823 | ||||||||||||||||||